| C(DH) | Suzuki, K.Suzuki, Kurt >> | 25 | 2008 | R | 60 | 43 | 99 | 148 | .279 | .347 | .370 | .717 | .310 | 530 | 54 | 148 | 25 | 1 | 7 | 42 | 44 | 69 | 11 | 2 | .994 | - | +1.99 | 2 | +2.73 | 14 | C |
| C(DH) | Doumit, R.Doumit, Ryan † # >> | 27 | 2008 | S | 89 | 88 | 66 | 116 | .318 | .361 | .501 | .862 | .320 | 431 | 71 | 137 | 34 | 0 | 15 | 69 | 23 | 55 | 6 | 2 | .988 | - | +0.49 | 2 | +3.43 | 6 | C |
| 1B(3B) | Youkilis, K.Youkilis, Kevin >> | 29 | 2008 | R | 98 | 97 | 79 | 145 | .312 | .395 | .569 | .964 | .360 | 538 | 91 | 168 | 43 | 4 | 29 | 115 | 62 | 108 | 12 | 3 | .994 | - | +0.52 | 3 | +5.12 | 12 | C |
| 2B(IF) | Roberts, B.Roberts, Brian >> | 31 | 2008 | S | 92 | 86 | 67 | 155 | .296 | .381 | .450 | .831 | .340 | 611 | 107 | 181 | 51 | 8 | 9 | 57 | 82 | 104 | 2 | 40 | .989 | - | +0.48 | 8 | +5.1 | 25 | C |
| 2B(OF) | DeRosa, M.DeRosa, Mark >> | 33 | 2008 | R | 73 | 82 | 5 | 149 | .285 | .381 | .481 | .862 | .340 | 505 | 103 | 144 | 30 | 3 | 21 | 87 | 69 | 106 | 9 | 6 | .977 | - | -1.92 | 4 | +3.65 | 14 | C |
| 2B(IF) | Johnson, K.Johnson, Kelly >> | 26 | 2008 | L | 56 | 65 | 31 | 150 | .287 | .351 | .446 | .797 | .310 | 547 | 86 | 157 | 39 | 6 | 12 | 69 | 52 | 113 | 2 | 11 | .980 | - | -0.45 | 5 | +2.96 | 16 | C |
| 3B(1B) | Glaus, T.Glaus, Troy # >> | 32 | 2008 | R | 80 | 70 | 72 | 151 | .270 | .374 | .483 | .857 | .340 | 544 | 69 | 147 | 33 | 1 | 27 | 99 | 87 | 104 | 3 | 0 | .983 | - | +0.86 | 2 | +3.71 | 17 | C |
| SS(IF) | Cabrera, O.Cabrera, Orlando >> | 34 | 2008 | R | 45 | 38 | 73 | 161 | .281 | .338 | .371 | .709 | .300 | 661 | 93 | 186 | 33 | 1 | 8 | 57 | 56 | 71 | 1 | 19 | .978 | - | +1.11 | 4 | +2.23 | 164 | C |
| OF(DH) | Sizemore, G.Sizemore, Grady >> | 26 | 2008 | L | 82 | 73 | 70 | 157 | .268 | .376 | .502 | .878 | .340 | 634 | 101 | 170 | 39 | 5 | 33 | 90 | 98 | 130 | 11 | 38 | .995 | - | +0.08 | 7 | +6.07 | 34 | C |
| OF(OF) | Sweeney, R.Sweeney, Ryan >> | 23 | 2008 | L | 64 | 56 | 68 | 115 | .286 | .355 | .383 | .738 | .320 | 384 | 53 | 110 | 18 | 2 | 5 | 45 | 38 | 67 | 3 | 9 | .996 | - | -0.01 | 5 | +1.78 | 5 | C |