| C(1B) | Perez, S.Perez, Salvador >> | 31 | 2021 | R | 83 | 76 | 99 | 161 | .273 | .318 | .544 | .862 | .290 | 620 | 88 | 169 | 24 | 0 | 48 | 121 | 28 | 170 | 13 | 1 | .998 | + | +1.2 | 1 | +4.6 | 164 | C |
| C(1B) | Realmuto, J.Realmuto, J.T. $ >> | 30 | 2021 | R | 85 | 75 | 91 | 134 | .263 | .344 | .439 | .783 | .320 | 476 | 64 | 125 | 25 | 4 | 17 | 73 | 48 | 129 | 11 | 13 | .998 | - | +0.4 | 5 | +3.6 | 8 | C |
| 1B(DH) | Goldschmidt, P.Goldschmidt, Paul >> | 33 | 2021 | R | 96 | 94 | 67 | 158 | .294 | .368 | .514 | .882 | .340 | 603 | 102 | 177 | 36 | 2 | 31 | 99 | 67 | 136 | 4 | 12 | .998 | - | -0.1 | 4 | +5.3 | 42 | C |
| 2B(IF) | Madrigal, N.Madrigal, Nick >> | 24 | 2021 | R | 79 | 84 | 28 | 54 | .305 | .350 | .425 | .775 | .320 | 200 | 30 | 61 | 10 | 4 | 2 | 21 | 11 | 17 | 3 | 1 | .973 | - | -0.2 | 5 | +1.6 | 4 | C |
| 2B(IF) | Altuve, J.Altuve, Jose >> | 31 | 2021 | R | 87 | 87 | 56 | 146 | .278 | .353 | .489 | .842 | .330 | 601 | 117 | 167 | 32 | 1 | 31 | 83 | 66 | 91 | 4 | 5 | .985 | - | +0.2 | 2 | +4.7 | 12 | C |
| 3B(IF) | Rendon, A.Rendon, Anthony >> | 31 | 2021 | R | 49 | 47 | 40 | 58 | .240 | .332 | .382 | .714 | .300 | 217 | 24 | 52 | 13 | 0 | 6 | 34 | 29 | 41 | 1 | 0 | .993 | - | -0.5 | 1 | +0.6 | 5 | C |
| 3B(1B) | Franco, M.Franco, Maikel >> | 28 | 2021 | R | 2 | 8 | 12 | 104 | .210 | .255 | .355 | .610 | .230 | 377 | 31 | 79 | 22 | 0 | 11 | 47 | 20 | 67 | 3 | 0 | .967 | - | -0.5 | 1 | -0.8 | 6 | C |
| SS(IF) | Story, T.Story, Trevor >> | 28 | 2021 | R | 76 | 68 | 81 | 142 | .251 | .332 | .471 | .803 | .300 | 526 | 88 | 132 | 34 | 5 | 24 | 75 | 53 | 139 | 11 | 20 | .975 | - | +1.6 | 6 | +3.4 | 10 | C |
| SS(IF) | Bogaerts, X.Bogaerts, Xander >> | 28 | 2021 | R | 95 | 95 | 61 | 144 | .295 | .374 | .493 | .867 | .350 | 529 | 90 | 156 | 34 | 1 | 23 | 79 | 62 | 113 | 5 | 5 | .983 | - | +0.3 | 2 | +5.4 | 11 | C |
| OF(1B) | Harper, B.Harper, Bryce $ >> | 28 | 2021 | L | 94 | 100 | 22 | 141 | .309 | .432 | .615 | 1.047 | .400 | 488 | 101 | 151 | 42 | 1 | 35 | 84 | 100 | 134 | 5 | 13 | .996 | - | -1.2 | 4 | +6.5 | 10 | C |
| OF(2B) | Betts, M.Betts, Mookie $ >> | 28 | 2021 | R | 89 | 86 | 59 | 122 | .264 | .371 | .487 | .858 | .340 | 466 | 93 | 123 | 29 | 3 | 23 | 58 | 68 | 86 | 11 | 10 | .986 | - | +0.2 | 5 | +3.7 | 6 | C |
| OF(3B) | Bryant, K.Bryant, Kris >> | 29 | 2021 | R | 70 | 82 | 5 | 144 | .265 | .354 | .481 | .835 | .330 | 513 | 86 | 136 | 32 | 2 | 25 | 73 | 62 | 135 | 9 | 10 | .974 | + | -0.9 | 4 | +3.8 | 11 | C |