| C(1B) | McCann, B.McCann, Brian >> | 26 | 2010 | L | 84 | 73 | 73 | 143 | .269 | .377 | .453 | .830 | .340 | 479 | 63 | 129 | 25 | 0 | 21 | 77 | 74 | 98 | 9 | 5 | .987 | - | +0.68 | 2 | +3.71 | 11 | C |
| C(1B) | Posada, J.Posada, Jorge >> | 39 | 2010 | S | 54 | 57 | 24 | 120 | .248 | .359 | .454 | .813 | .330 | 383 | 49 | 95 | 23 | 1 | 18 | 57 | 59 | 99 | 7 | 3 | .986 | - | -1.13 | 2 | +2.7 | 6 | C |
| 1B(DH) | Pujols, A.Pujols, Albert >> | 30 | 2010 | R | 98 | 99 | 66 | 159 | .312 | .418 | .596 | 1.014 | .390 | 587 | 115 | 183 | 39 | 1 | 42 | 118 | 103 | 76 | 4 | 14 | .998 | - | -0.18 | 4 | +6.64 | 56 | C |
| 1B(DH) | Konerko, P.Konerko, Paul >> | 34 | 2010 | R | 91 | 98 | 20 | 149 | .312 | .397 | .584 | .981 | .360 | 548 | 89 | 171 | 30 | 1 | 39 | 111 | 72 | 110 | 5 | 0 | .994 | - | -2.28 | 2 | +6.01 | 14 | C |
| 1B(DH) | Teixeira, M.Teixeira, Mark >> | 30 | 2010 | S | 75 | 65 | 63 | 158 | .256 | .368 | .481 | .849 | .340 | 601 | 113 | 154 | 36 | 0 | 33 | 108 | 93 | 122 | 13 | 0 | .998 | - | -0.3 | 1 | +3.42 | 42 | C |
| 2B(IF) | Sanchez, F.Sanchez, Freddy >> | 33 | 2010 | R | 66 | 62 | 56 | 111 | .292 | .345 | .397 | .742 | .310 | 431 | 55 | 126 | 22 | 1 | 7 | 47 | 32 | 68 | 3 | 3 | .991 | - | -0.09 | 2 | +2.15 | 5 | C |
| 3B(2B) | Polanco, P.Polanco, Placido >> | 35 | 2010 | R | 73 | 61 | 90 | 132 | .298 | .344 | .386 | .730 | .310 | 554 | 76 | 165 | 27 | 2 | 6 | 52 | 32 | 47 | 7 | 5 | .988 | - | +1.38 | 3 | +1.98 | 7 | C |
| SS(2B) | Carroll, J.Carroll, Jamey >> | 36 | 2010 | R | 83 | 70 | 72 | 133 | .291 | .384 | .339 | .723 | .350 | 351 | 48 | 102 | 15 | 1 | 0 | 23 | 51 | 64 | 2 | 12 | .986 | - | +0.54 | 5 | +2.39 | 8 | C |
| SS(IF) | Renteria, E.Renteria, Edgar >> | 35 | 2010 | R | 45 | 47 | 48 | 72 | .276 | .333 | .374 | .707 | .300 | 243 | 26 | 67 | 11 | 2 | 3 | 22 | 21 | 43 | 0 | 3 | .983 | - | +0.1 | 4 | +0.77 | 5 | C |
| OF(OF) | Crawford, C.Crawford, Carl >> | 29 | 2010 | L | 88 | 87 | 75 | 154 | .307 | .359 | .495 | .854 | .330 | 600 | 110 | 184 | 30 | 13 | 19 | 90 | 46 | 104 | 3 | 47 | .994 | - | +0.26 | 8 | +6.08 | 22 | C |
| OF(OF) | Spilborghs, R.Spilborghs, Ryan >> | 31 | 2010 | R | 60 | 70 | 5 | 134 | .279 | .361 | .437 | .798 | .330 | 341 | 41 | 95 | 20 | 2 | 10 | 39 | 39 | 83 | 5 | 4 | .964 | - | -1.47 | 4 | +0.64 | 8 | C |
| OF(2B) | Zobrist, B.Zobrist, Ben >> | 29 | 2010 | S | 56 | 33 | 94 | 151 | .238 | .352 | .353 | .705 | .320 | 541 | 77 | 129 | 28 | 2 | 10 | 75 | 92 | 107 | 3 | 24 | .992 | + | +1.37 | 6 | +2.83 | 17 | C |
| OF(OF) | Ramirez, M.Ramirez, Manny # >> | 38 | 2010 | R | 85 | 94 | 4 | 90 | .298 | .413 | .460 | .873 | .380 | 265 | 38 | 79 | 16 | 0 | 9 | 42 | 46 | 61 | 6 | 1 | .959 | - | -1.45 | 2 | +1.78 | 5 | C |