| C(3B) | Cervelli, F.Cervelli, Francisco >> | 24 | 2010 | R | 61 | 56 | 53 | 93 | .271 | .364 | .335 | .699 | .330 | 266 | 27 | 72 | 11 | 3 | 0 | 38 | 33 | 42 | 6 | 1 | .980 | - | +0.29 | 4 | +1.17 | 5 | C |
| C(1B) | Hernandez, R.Hernandez, Ramon >> | 34 | 2010 | R | 80 | 77 | 52 | 97 | .297 | .366 | .428 | .794 | .330 | 313 | 30 | 93 | 18 | 1 | 7 | 48 | 29 | 49 | 5 | 0 | .994 | - | -0.34 | 2 | +1.92 | 5 | C |
| C(1B) | Rodriguez, I.Rodriguez, Ivan >> | 39 | 2010 | R | 28 | 18 | 91 | 111 | .266 | .296 | .347 | .643 | .260 | 398 | 32 | 106 | 18 | 1 | 4 | 49 | 16 | 66 | 1 | 2 | .995 | - | +0.84 | 2 | -0.31 | 5 | C |
| 1B(3B) | Youkilis, K.Youkilis, Kevin † # >> | 31 | 2010 | R | 99 | 99 | 75 | 102 | .307 | .416 | .564 | .980 | .380 | 362 | 77 | 111 | 26 | 5 | 19 | 62 | 58 | 67 | 10 | 4 | .997 | - | +0.09 | 5 | +4.71 | 6 | C |
| 1B(DH) | Barton, D.Barton, Daric >> | 25 | 2010 | L | 92 | 76 | 93 | 159 | .273 | .396 | .405 | .801 | .360 | 556 | 79 | 152 | 33 | 5 | 10 | 57 | 110 | 102 | 3 | 7 | .993 | - | +1.07 | 4 | +3.55 | 56 | C |
| 1B(DH) | Fielder, P.Fielder, Prince >> | 26 | 2010 | L | 79 | 80 | 25 | 161 | .261 | .401 | .471 | .872 | .370 | 578 | 94 | 151 | 25 | 0 | 32 | 83 | 114 | 128 | 21 | 1 | .997 | - | -2.86 | 1 | +3.29 | 164 | C |
| 2B(IF) | Johnson, K.Johnson, Kelly >> | 28 | 2010 | L | 88 | 85 | 67 | 154 | .284 | .371 | .496 | .867 | .340 | 585 | 93 | 166 | 36 | 5 | 26 | 71 | 79 | 148 | 2 | 13 | .988 | - | +0.29 | 5 | +4.23 | 22 | C |
| 2B(IF) | Weeks, R.Weeks, Rickie >> | 28 | 2010 | R | 65 | 71 | 13 | 160 | .269 | .367 | .464 | .831 | .330 | 651 | 112 | 175 | 32 | 4 | 29 | 83 | 76 | 184 | 25 | 11 | .980 | - | -1.35 | 4 | +5.21 | 83 | C |
| 2B(3B) | Herrera, J.Herrera, Jonathan >> | 26 | 2010 | S | 69 | 58 | 75 | 76 | .284 | .356 | .342 | .698 | .320 | 222 | 34 | 63 | 6 | 2 | 1 | 21 | 25 | 36 | 0 | 2 | .985 | - | +0.82 | 4 | +0.3 | 5 | C |
| 3B(IF) | Johnson, C.Johnson, Chris >> | 25 | 2010 | R | 57 | 75 | 2 | 94 | .308 | .341 | .481 | .822 | .310 | 341 | 40 | 105 | 22 | 2 | 11 | 52 | 15 | 91 | 2 | 3 | .908 | - | -1.54 | 3 | +1.98 | 5 | C |
| SS(IF) | Hardy, J.Hardy, J.J. # >> | 28 | 2010 | R | 34 | 38 | 41 | 101 | .268 | .323 | .394 | .717 | .290 | 340 | 44 | 91 | 19 | 3 | 6 | 38 | 28 | 54 | 0 | 1 | .976 | - | +0.04 | 3 | +1.82 | 6 | C |
| OF(OF) | Wells, V.Wells, Vernon >> | 32 | 2010 | R | 65 | 62 | 70 | 157 | .273 | .333 | .515 | .848 | .300 | 590 | 79 | 161 | 44 | 3 | 31 | 88 | 50 | 84 | 3 | 6 | 1.000 | - | -0.14 | 3 | +4.51 | 34 | C |
| OF(OF) | Willingham, J.Willingham, Josh >> | 31 | 2010 | R | 83 | 78 | 51 | 114 | .268 | .392 | .459 | .851 | .360 | 370 | 54 | 99 | 19 | 2 | 16 | 56 | 67 | 85 | 9 | 8 | .994 | - | -0.4 | 5 | +2.64 | 5 | C |
| OF(OF) | Murphy, D.Murphy, David >> | 29 | 2010 | L | 77 | 76 | 50 | 138 | .291 | .360 | .449 | .809 | .330 | 419 | 54 | 122 | 26 | 2 | 12 | 65 | 45 | 71 | 0 | 14 | .995 | - | -0.48 | 5 | +2.55 | 9 | C |
| OF(OF) | Young, D.Young, Delmon >> | 25 | 2010 | R | 58 | 73 | 12 | 153 | .298 | .338 | .493 | .831 | .310 | 570 | 77 | 170 | 46 | 1 | 21 | 112 | 28 | 81 | 6 | 5 | .984 | - | -1.92 | 2 | +3.16 | 20 | C |