| RP | Raley, B.Raley, Brooks >> | 33 | 2021 | L | 69 | 2 | 3 | 4.78 | .273 | .310 | 1.20 | 7.9 | 2.9 | 11.9 | 49 | 43 | 6 | 16 | 65 | 0 | 2 | 1 | 23 | 23 | C |
| RP | Maton, P.Maton, Phil >> | 28 | 2021 | R | 42 | 6 | 0 | 4.73 | .316 | .350 | 1.45 | 8.7 | 4.4 | 11.6 | 66 | 64 | 6 | 32 | 85 | 0 | 0 | 0 | 23 | 22 | C |
| RP | Taylor, B.Taylor, Blake >> | 25 | 2021 | L | 44 | 4 | 4 | 3.16 | .306 | .350 | 1.43 | 8.1 | 4.7 | 8.8 | 42 | 38 | 6 | 22 | 41 | 0 | 0 | 5 | 23 | 20 | C |
| RP | Garza, R.Garza, Ralph >> | 27 | 2021 | R | 62 | 1 | 4 | 3.56 | .275 | .320 | 1.27 | 7.2 | 4.2 | 8.7 | 30 | 24 | 5 | 14 | 29 | 0 | 1 | 1 | 23 | 19 | C |
| SP | Garcia, L.Garcia, Luis >> | 24 | 2021 | R | 80 | 11 | 8 | 3.30 | .277 | .310 | 1.17 | 7.7 | 2.9 | 9.7 | 155 | 132 | 19 | 50 | 167 | 0 | 0 | 9 | 92 | 19 | C |
| RP | Graveman, K.Graveman, Kendall >> | 30 | 2021 | R | 96 | 5 | 1 | 1.77 | .236 | .270 | 0.98 | 5.6 | 3.2 | 9.8 | 56 | 35 | 3 | 20 | 61 | 0 | 10 | 3 | 23 | 20 | C |
| RP | Smith, J.Smith, Joe >> | 37 | 2021 | R | 28 | 4 | 4 | 4.99 | .302 | .350 | 1.41 | 10.8 | 1.8 | 7.8 | 39 | 47 | 5 | 8 | 34 | 0 | 0 | 2 | 23 | 18 | C |
| SP | Greinke, Z.Greinke, Zack >> | 38 | 2021 | R | 61 | 11 | 6 | 4.16 | .277 | .310 | 1.17 | 8.6 | 1.9 | 6.3 | 171 | 164 | 30 | 36 | 120 | 1 | 0 | 3 | 101 | 16 | C |
| RP | Scrubb, A.Scrubb, Andre >> | 26 | 2021 | R | 46 | 1 | 1 | 5.03 | .302 | .370 | 1.53 | 7.1 | 6.6 | 9.9 | 19 | 15 | 5 | 14 | 21 | 0 | 0 | 2 | 23 | 20 | C |
| RP | Pressly, R.Pressly, Ryan >> | 32 | 2021 | R | 92 | 5 | 3 | 2.25 | .235 | .270 | 0.97 | 6.9 | 1.8 | 11.4 | 64 | 49 | 4 | 13 | 81 | 0 | 26 | 3 | 23 | 21 | C |
| RP | Garcia, Y.Garcia, Yimi >> | 30 | 2021 | R | 68 | 4 | 9 | 4.21 | .270 | .310 | 1.18 | 7.7 | 2.8 | 9.5 | 57 | 49 | 8 | 18 | 60 | 0 | 15 | 0 | 23 | 20 | C |
| SP | Odorizzi, J.Odorizzi, Jake >> | 31 | 2021 | R | 53 | 6 | 7 | 4.21 | .289 | .320 | 1.26 | 8.4 | 2.9 | 7.9 | 104 | 97 | 16 | 34 | 91 | 0 | 0 | 0 | 78 | 18 | C |
| RP | Montero, R.Montero, Rafael >> | 30 | 2021 | R | 16 | 5 | 4 | 6.39 | .326 | .370 | 1.55 | 10.8 | 3.1 | 7.7 | 49 | 59 | 4 | 17 | 42 | 0 | 7 | 4 | 23 | 18 | C |
| RP | Abreu, B.Abreu, Bryan >> | 24 | 2021 | R | 35 | 3 | 3 | 5.75 | .310 | .360 | 1.47 | 8.8 | 4.5 | 9.0 | 36 | 35 | 4 | 18 | 36 | 0 | 1 | 4 | 24 | 19 | C |
| RP | Javier, C.Javier, Cristian >> | 24 | 2021 | R | 84 | 4 | 1 | 3.55 | .277 | .310 | 1.19 | 6.0 | 4.7 | 11.6 | 101 | 67 | 16 | 53 | 130 | 0 | 2 | 6 | 52 | 21 | C |
| RP | Emanuel, K.Emanuel, Kent >> | 29 | 2021 | L | 88 | 1 | 0 | 2.55 | .208 | .270 | 0.94 | 6.4 | 2.1 | 6.9 | 17 | 12 | 4 | 4 | 13 | 0 | 0 | 0 | 33 | 23 | C |
| SP | Valdez, F.Valdez, Framber >> | 27 | 2021 | L | 68 | 11 | 6 | 3.14 | .290 | .320 | 1.25 | 7.4 | 3.9 | 8.4 | 134 | 110 | 12 | 58 | 125 | 1 | 0 | 9 | 108 | 18 | C |
| RP | Bielak, B.Bielak, Brandon >> | 25 | 2021 | R | 43 | 3 | 4 | 4.50 | .301 | .340 | 1.38 | 8.6 | 3.8 | 8.3 | 50 | 48 | 5 | 21 | 46 | 0 | 1 | 4 | 34 | 19 | C |
| SP | McCullers, L.McCullers, Lance >> | 28 | 2021 | R | 79 | 13 | 5 | 3.16 | .285 | .320 | 1.22 | 6.8 | 4.2 | 10.3 | 162 | 122 | 13 | 76 | 185 | 0 | 0 | 7 | 102 | 20 | C |
| SP | Urquidy, J.Urquidy, Jose >> | 26 | 2021 | R | 88 | 8 | 3 | 3.62 | .243 | .280 | 0.99 | 7.3 | 1.6 | 7.6 | 107 | 87 | 17 | 19 | 90 | 0 | 0 | 2 | 95 | 18 | C |
| RP | Stanek, R.Stanek, Ryne >> | 29 | 2021 | R | 79 | 3 | 5 | 3.42 | .279 | .320 | 1.22 | 6.1 | 4.9 | 11.0 | 68 | 46 | 8 | 37 | 83 | 0 | 2 | 6 | 23 | 21 | C |