| RP | Greene, S.Greene, Shane >> | 32 | 2021 | R | 17 | 0 | 1 | 7.23 | .331 | .390 | 1.70 | 9.8 | 5.5 | 9.4 | 23 | 25 | 6 | 14 | 24 | 0 | 1 | 1 | 23 | 22 | C |
| RP | Gonzalez, V.Gonzalez, Victor >> | 25 | 2021 | L | 39 | 3 | 1 | 3.57 | .307 | .350 | 1.46 | 8.2 | 4.9 | 8.5 | 35 | 32 | 3 | 19 | 33 | 0 | 1 | 1 | 23 | 21 | C |
| RP | White, M.White, Mitch >> | 26 | 2021 | R | 70 | 1 | 3 | 3.66 | .271 | .310 | 1.20 | 7.4 | 3.3 | 9.6 | 46 | 38 | 6 | 17 | 49 | 0 | 0 | 3 | 41 | 19 | C |
| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 99 | 15 | 4 | 2.46 | .221 | .250 | 0.87 | 6.0 | 1.8 | 11.9 | 179 | 119 | 23 | 36 | 236 | 1 | 0 | 2 | 105 | 22 | C |
| RP | Bruihl, J.Bruihl, Justin >> | 24 | 2021 | L | 76 | 0 | 1 | 2.89 | .238 | .300 | 1.11 | 6.5 | 3.5 | 5.5 | 18 | 13 | 1 | 7 | 11 | 0 | 0 | 3 | 23 | 15 | C |
| SP | Kershaw, C.Kershaw, Clayton >> | 33 | 2021 | L | 91 | 10 | 8 | 3.55 | .249 | .280 | 1.02 | 7.7 | 1.6 | 10.7 | 121 | 103 | 15 | 21 | 144 | 0 | 0 | 7 | 98 | 21 | C |
| SP | Gonsolin, T.Gonsolin, Tony >> | 27 | 2021 | R | 60 | 4 | 1 | 3.23 | .300 | .340 | 1.36 | 6.7 | 5.6 | 10.6 | 55 | 41 | 8 | 34 | 65 | 0 | 0 | 4 | 66 | 20 | C |
| RP | Nelson, J.Nelson, Jimmy >> | 32 | 2021 | R | 100 | 1 | 2 | 1.86 | .218 | .260 | 0.93 | 4.3 | 4.0 | 13.7 | 29 | 14 | 0 | 13 | 44 | 0 | 0 | 4 | 23 | 24 | C |
| SP | May, D.May, Dustin >> | 23 | 2021 | R | 98 | 1 | 1 | 2.74 | .218 | .270 | 0.96 | 6.3 | 2.3 | 13.7 | 23 | 16 | 4 | 6 | 35 | 0 | 0 | 0 | 82 | 27 | C |
| SP | Bauer, T.Bauer, Trevor >> | 30 | 2021 | R | 96 | 8 | 5 | 2.59 | .246 | .280 | 1.01 | 6.0 | 3.1 | 11.5 | 107 | 71 | 19 | 37 | 137 | 1 | 0 | 3 | 111 | 22 | C |
| RP | Bickford, P.Bickford, Phil >> | 25 | 2021 | R | 92 | 4 | 2 | 2.50 | .245 | .290 | 1.04 | 6.1 | 3.2 | 10.6 | 50 | 34 | 6 | 18 | 59 | 0 | 1 | 0 | 23 | 21 | C |
| RP | Uceta, E.Uceta, Edwin >> | 23 | 2021 | R | 36 | 0 | 3 | 6.64 | .307 | .370 | 1.55 | 8.6 | 5.4 | 11.3 | 20 | 19 | 3 | 12 | 25 | 0 | 0 | 1 | 28 | 22 | C |
| RP | Vesia, A.Vesia, Alex >> | 25 | 2021 | L | 99 | 3 | 1 | 2.25 | .231 | .270 | 0.98 | 3.8 | 5.0 | 12.2 | 40 | 17 | 6 | 22 | 54 | 0 | 1 | 0 | 23 | 23 | C |
| RP | Jansen, K.Jansen, Kenley >> | 33 | 2021 | R | 96 | 4 | 4 | 2.22 | .249 | .290 | 1.04 | 4.7 | 4.7 | 11.2 | 69 | 36 | 4 | 36 | 86 | 0 | 38 | 4 | 23 | 22 | C |
| SP | Buehler, W.Buehler, Walker >> | 26 | 2021 | R | 95 | 16 | 4 | 2.47 | .242 | .270 | 0.97 | 6.5 | 2.3 | 9.2 | 207 | 149 | 19 | 52 | 212 | 0 | 0 | 5 | 111 | 19 | C |
| RP | Cleavinger, G.Cleavinger, Garrett >> | 27 | 2021 | L | 13 | 2 | 4 | 3.00 | .333 | .400 | 1.78 | 10.0 | 6.0 | 10.5 | 18 | 20 | 4 | 12 | 21 | 0 | 0 | 0 | 23 | 20 | C |
| RP | Kelly, J.Kelly, Joe >> | 33 | 2021 | R | 96 | 2 | 0 | 2.86 | .232 | .270 | 0.98 | 5.7 | 3.1 | 10.2 | 44 | 28 | 3 | 15 | 50 | 0 | 2 | 0 | 23 | 22 | C |
| RP | Treinen, B.Treinen, Blake >> | 33 | 2021 | R | 94 | 6 | 5 | 1.99 | .239 | .280 | 0.99 | 5.8 | 3.1 | 10.6 | 72 | 46 | 5 | 25 | 85 | 0 | 7 | 3 | 23 | 20 | C |
| SP | Urias, J.Urias, Julio >> | 24 | 2021 | L | 92 | 20 | 3 | 2.96 | .251 | .280 | 1.02 | 7.3 | 1.8 | 9.5 | 185 | 151 | 19 | 38 | 195 | 0 | 0 | 2 | 102 | 19 | C |
| RP | Alexander, S.Alexander, Scott >> | 31 | 2021 | L | 45 | 0 | 2 | 2.93 | .257 | .320 | 1.27 | 9.0 | 2.4 | 4.8 | 15 | 15 | 2 | 4 | 8 | 0 | 0 | 1 | 23 | 18 | C |
| RP | Graterol, B.Graterol, Brusdar >> | 22 | 2021 | R | 32 | 3 | 0 | 4.59 | .301 | .350 | 1.42 | 9.3 | 3.5 | 7.4 | 33 | 34 | 2 | 13 | 27 | 0 | 0 | 2 | 23 | 19 | C |
| RP | Knebel, C.Knebel, Corey >> | 29 | 2021 | R | 94 | 4 | 0 | 2.45 | .227 | .280 | 1.00 | 5.8 | 3.2 | 10.8 | 25 | 16 | 2 | 9 | 30 | 0 | 3 | 0 | 23 | 25 | C |
| RP | Jones, N.Jones, Nate >> | 35 | 2021 | R | 40 | 0 | 2 | 5.68 | .295 | .360 | 1.47 | 7.6 | 5.7 | 6.6 | 19 | 16 | 7 | 12 | 14 | 0 | 0 | 1 | 23 | 17 | C |
| RP | Sherfy, J.Sherfy, Jimmie >> | 29 | 2021 | R | 76 | 2 | 1 | 4.20 | .225 | .290 | 1.07 | 7.2 | 2.4 | 7.2 | 15 | 12 | 3 | 4 | 12 | 0 | 0 | 1 | 23 | 22 | C |
| RP | Price, D.Price, David >> | 36 | 2021 | L | 27 | 5 | 2 | 4.03 | .314 | .350 | 1.44 | 9.7 | 3.2 | 7.2 | 73 | 79 | 8 | 26 | 58 | 0 | 1 | 1 | 36 | 17 | C |
| RP | Santana, D.Santana, Dennis >> | 25 | 2021 | R | 38 | 2 | 4 | 4.28 | .317 | .360 | 1.48 | 8.0 | 5.3 | 7.7 | 54 | 48 | 4 | 32 | 46 | 0 | 0 | 4 | 23 | 17 | C |
| SP | Gray, J.Gray, Josiah >> | 23 | 2021 | R | 46 | 2 | 2 | 5.48 | .304 | .340 | 1.37 | 8.1 | 4.2 | 9.8 | 70 | 63 | 19 | 33 | 76 | 0 | 0 | 7 | 89 | 20 | C |