| RP | Thompson, K.Thompson, Keegan >> | 26 | 2021 | R | 38 | 3 | 3 | 3.38 | .319 | .360 | 1.49 | 8.2 | 5.3 | 9.3 | 53 | 48 | 9 | 31 | 55 | 0 | 1 | 4 | 32 | 21 | C |
| RP | Abbott, C.Abbott, Cory >> | 25 | 2021 | R | 6 | 0 | 0 | 6.75 | .337 | .410 | 1.82 | 10.6 | 5.8 | 6.4 | 17 | 20 | 7 | 11 | 12 | 0 | 0 | 2 | 45 | 22 | C |
| RP | Wick, R.Wick, Rowan >> | 28 | 2021 | R | 67 | 0 | 1 | 4.30 | .282 | .340 | 1.35 | 6.7 | 5.5 | 11.3 | 23 | 17 | 1 | 14 | 29 | 0 | 5 | 1 | 23 | 24 | C |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 99 | 4 | 5 | 2.26 | .224 | .260 | 0.92 | 4.7 | 3.5 | 15.3 | 59 | 31 | 6 | 23 | 100 | 0 | 24 | 8 | 23 | 26 | C |
| SP | Arrieta, J.Arrieta, Jake >> | 35 | 2021 | R | 4 | 5 | 14 | 7.39 | .365 | .400 | 1.79 | 12.0 | 4.0 | 7.6 | 98 | 131 | 24 | 44 | 83 | 0 | 0 | 3 | 73 | 18 | C |
| SP | Alzolay, A.Alzolay, Adbert >> | 26 | 2021 | R | 76 | 5 | 13 | 4.58 | .275 | .310 | 1.17 | 8.1 | 2.4 | 9.2 | 125 | 112 | 25 | 34 | 128 | 0 | 1 | 2 | 77 | 19 | C |
| SP | Davies, Z.Davies, Zach >> | 28 | 2021 | R | 16 | 6 | 12 | 5.78 | .343 | .380 | 1.60 | 9.9 | 4.6 | 6.9 | 148 | 162 | 25 | 75 | 114 | 0 | 0 | 0 | 83 | 17 | C |
| RP | Morgan, A.Morgan, Adam >> | 31 | 2021 | R | 54 | 2 | 1 | 4.26 | .286 | .340 | 1.36 | 7.9 | 4.3 | 10.1 | 25 | 22 | 6 | 12 | 28 | 0 | 2 | 0 | 23 | 24 | C |
| SP | Sampson, A.Sampson, Adrian >> | 29 | 2021 | R | 79 | 1 | 2 | 2.80 | .248 | .290 | 1.09 | 7.7 | 2.1 | 7.2 | 35 | 30 | 8 | 8 | 28 | 0 | 0 | 1 | 64 | 19 | C |
| RP | Megill, T.Megill, Trevor >> | 27 | 2021 | R | 8 | 1 | 2 | 8.37 | .358 | .420 | 1.91 | 14.1 | 3.1 | 11.7 | 23 | 36 | 7 | 8 | 30 | 0 | 0 | 5 | 23 | 25 | C |
| RP | Chafin, A.Chafin, Andrew >> | 31 | 2021 | L | 93 | 2 | 4 | 1.83 | .230 | .270 | 0.94 | 6.0 | 2.5 | 8.5 | 68 | 45 | 4 | 19 | 64 | 0 | 5 | 3 | 23 | 19 | C |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 99 | 0 | 2 | 2.79 | .219 | .260 | 0.89 | 5.2 | 2.8 | 10.9 | 61 | 35 | 4 | 19 | 74 | 0 | 2 | 4 | 23 | 22 | C |
| RP | Wieck, B.Wieck, Brad >> | 29 | 2021 | L | 89 | 0 | 0 | 0.00 | .247 | .310 | 1.18 | 5.3 | 5.3 | 14.8 | 17 | 10 | 0 | 10 | 28 | 0 | 0 | 0 | 23 | 38 | C |
| RP | Brothers, R.Brothers, Rex >> | 33 | 2021 | L | 60 | 3 | 2 | 5.26 | .310 | .350 | 1.43 | 7.0 | 5.9 | 12.7 | 53 | 41 | 9 | 35 | 75 | 0 | 1 | 5 | 23 | 25 | C |
| RP | Nance, T.Nance, Tommy >> | 30 | 2021 | R | 52 | 1 | 1 | 7.22 | .288 | .340 | 1.36 | 8.0 | 4.2 | 9.6 | 28 | 25 | 5 | 13 | 30 | 0 | 0 | 7 | 23 | 20 | C |
| RP | Rucker, M.Rucker, Michael >> | 27 | 2021 | R | 24 | 0 | 0 | 6.99 | .314 | .370 | 1.54 | 10.3 | 3.5 | 9.6 | 28 | 32 | 5 | 11 | 30 | 0 | 1 | 0 | 28 | 20 | C |
| SP | Hendricks, K.Hendricks, Kyle >> | 31 | 2021 | R | 30 | 14 | 7 | 4.77 | .306 | .340 | 1.35 | 9.9 | 2.2 | 6.5 | 181 | 200 | 31 | 44 | 131 | 1 | 0 | 2 | 100 | 16 | C |
| RP | Winkler, D.Winkler, Dan >> | 31 | 2021 | R | 38 | 1 | 3 | 5.22 | .328 | .370 | 1.59 | 7.4 | 6.9 | 9.2 | 39 | 32 | 5 | 30 | 40 | 0 | 0 | 3 | 23 | 20 | C |
| RP | Workman, B.Workman, Brandon >> | 32 | 2021 | R | 5 | 1 | 2 | 5.46 | .377 | .430 | 2.04 | 11.6 | 6.8 | 8.0 | 28 | 36 | 4 | 21 | 25 | 0 | 0 | 1 | 23 | 18 | C |
| RP | Heuer, C.Heuer, Codi >> | 24 | 2021 | R | 44 | 7 | 4 | 4.28 | .294 | .330 | 1.31 | 8.7 | 3.1 | 7.5 | 67 | 65 | 7 | 23 | 56 | 0 | 2 | 6 | 23 | 18 | C |
| RP | Maples, D.Maples, Dillon >> | 29 | 2021 | R | 77 | 1 | 0 | 2.59 | .280 | .330 | 1.29 | 4.4 | 7.3 | 11.6 | 31 | 15 | 2 | 25 | 40 | 0 | 0 | 5 | 23 | 23 | C |
| SP | Mills, A.Mills, Alec >> | 29 | 2021 | R | 23 | 6 | 7 | 5.07 | .318 | .350 | 1.44 | 10.4 | 2.6 | 6.6 | 119 | 137 | 16 | 34 | 87 | 0 | 1 | 4 | 67 | 16 | C |
| RP | Steele, J.Steele, Justin >> | 25 | 2021 | L | 53 | 4 | 4 | 4.26 | .298 | .340 | 1.35 | 7.9 | 4.3 | 9.3 | 57 | 50 | 12 | 27 | 59 | 0 | 0 | 0 | 52 | 19 | C |
| RP | Rodriguez, M.Rodriguez, Manuel >> | 24 | 2021 | R | 11 | 3 | 3 | 6.11 | .330 | .400 | 1.76 | 9.5 | 6.4 | 8.5 | 17 | 18 | 3 | 12 | 16 | 0 | 1 | 1 | 23 | 26 | C |
| SP | Williams, T.Williams, Trevor >> | 29 | 2021 | R | 24 | 4 | 2 | 4.35 | .325 | .360 | 1.49 | 10.4 | 3.1 | 8.9 | 91 | 105 | 11 | 31 | 90 | 0 | 0 | 0 | 71 | 19 | C |