| RP | Gant, J.Gant, John >> | 28 | 2021 | R | 35 | 5 | 11 | 4.09 | .328 | .360 | 1.51 | 7.8 | 5.8 | 7.5 | 110 | 95 | 10 | 71 | 92 | 0 | 0 | 3 | 52 | 17 | C |
| RP | Thielbar, C.Thielbar, Caleb >> | 34 | 2021 | L | 72 | 7 | 0 | 3.23 | .271 | .310 | 1.17 | 7.7 | 2.8 | 10.8 | 64 | 55 | 8 | 20 | 77 | 0 | 0 | 3 | 23 | 21 | C |
| RP | Anderson, S.Anderson, Shaun >> | 26 | 2021 | R | 2 | 0 | 0 | 8.49 | .378 | .440 | 2.09 | 14.1 | 4.7 | 7.4 | 23 | 36 | 4 | 12 | 19 | 0 | 0 | 3 | 28 | 19 | C |
| SP | Berrios, J.Berrios, Jose >> | 27 | 2021 | R | 87 | 12 | 9 | 3.52 | .258 | .290 | 1.06 | 7.5 | 2.1 | 9.6 | 192 | 159 | 22 | 45 | 204 | 1 | 0 | 3 | 106 | 19 | C |
| SP | Maeda, K.Maeda, Kenta >> | 33 | 2021 | R | 47 | 6 | 5 | 4.66 | .296 | .330 | 1.30 | 9.0 | 2.7 | 9.6 | 106 | 106 | 16 | 32 | 113 | 0 | 0 | 3 | 90 | 20 | C |
| SP | Jax, G.Jax, Griffin >> | 26 | 2021 | R | 35 | 4 | 5 | 6.37 | .302 | .340 | 1.35 | 9.0 | 3.2 | 7.1 | 82 | 82 | 23 | 29 | 65 | 0 | 0 | 6 | 81 | 17 | C |
| RP | Colome, A.Colome, Alex >> | 32 | 2021 | R | 36 | 4 | 4 | 4.15 | .307 | .350 | 1.40 | 9.4 | 3.2 | 8.0 | 65 | 68 | 8 | 23 | 58 | 0 | 17 | 2 | 23 | 18 | C |
| RP | Farrell, L.Farrell, Luke >> | 30 | 2021 | R | 13 | 1 | 1 | 4.74 | .333 | .390 | 1.71 | 10.5 | 4.9 | 9.4 | 24 | 28 | 4 | 13 | 25 | 0 | 0 | 0 | 24 | 22 | C |
| SP | Barnes, C.Barnes, Charlie >> | 25 | 2021 | L | 8 | 0 | 3 | 5.92 | .333 | .380 | 1.63 | 10.9 | 3.8 | 4.7 | 38 | 46 | 4 | 16 | 20 | 0 | 0 | 0 | 76 | 15 | C |
| SP | Ober, B.Ober, Bailey >> | 25 | 2021 | R | 61 | 3 | 3 | 4.19 | .280 | .310 | 1.21 | 9.0 | 1.9 | 9.4 | 92 | 92 | 20 | 19 | 96 | 0 | 0 | 1 | 82 | 19 | C |
| RP | Rogers, T.Rogers, Taylor >> | 30 | 2021 | L | 71 | 2 | 4 | 3.35 | .261 | .310 | 1.15 | 8.6 | 1.8 | 13.3 | 40 | 38 | 4 | 8 | 59 | 0 | 9 | 3 | 23 | 24 | C |
| RP | Garza, R.Garza, Ralph >> | 27 | 2021 | R | 62 | 1 | 4 | 3.56 | .275 | .320 | 1.27 | 7.2 | 4.2 | 8.7 | 30 | 24 | 5 | 14 | 29 | 0 | 1 | 1 | 23 | 19 | C |
| SP | Happ, J.Happ, J.A. >> | 39 | 2021 | L | 19 | 10 | 8 | 5.79 | .326 | .360 | 1.48 | 10.5 | 2.8 | 7.2 | 152 | 177 | 30 | 48 | 122 | 0 | 0 | 4 | 90 | 17 | C |
| RP | Duffey, T.Duffey, Tyler >> | 30 | 2021 | R | 70 | 3 | 3 | 3.18 | .279 | .320 | 1.23 | 7.0 | 4.1 | 8.9 | 62 | 48 | 4 | 28 | 61 | 0 | 3 | 5 | 23 | 20 | C |
| SP | Shoemaker, M.Shoemaker, Matt >> | 34 | 2021 | R | 5 | 3 | 8 | 8.06 | .345 | .390 | 1.67 | 11.0 | 4.1 | 6.0 | 60 | 73 | 15 | 27 | 40 | 0 | 0 | 1 | 68 | 16 | C |
| SP | Ryan, J.Ryan, Joe >> | 25 | 2021 | R | 99 | 2 | 1 | 4.05 | .193 | .240 | 0.81 | 5.5 | 1.7 | 10.4 | 26 | 16 | 4 | 5 | 30 | 0 | 0 | 1 | 92 | 25 | C |
| RP | Law, D.Law, Derek >> | 30 | 2021 | R | 20 | 0 | 0 | 4.20 | .304 | .380 | 1.60 | 9.6 | 4.8 | 8.4 | 15 | 16 | 2 | 8 | 14 | 0 | 0 | 1 | 32 | 24 | C |
| RP | Thorpe, L.Thorpe, Lewis >> | 25 | 2021 | L | 38 | 0 | 2 | 4.70 | .276 | .350 | 1.40 | 8.4 | 4.2 | 3.6 | 15 | 14 | 2 | 7 | 6 | 0 | 0 | 1 | 55 | 16 | C |
| SP | Albers, A.Albers, Andrew >> | 35 | 2021 | L | 3 | 1 | 2 | 7.58 | .330 | .390 | 1.74 | 11.4 | 4.3 | 5.7 | 19 | 24 | 9 | 9 | 12 | 0 | 0 | 0 | 69 | 16 | C |
| RP | Alcala, J.Alcala, Jorge >> | 25 | 2021 | R | 88 | 3 | 6 | 3.92 | .237 | .270 | 0.98 | 6.9 | 2.0 | 9.3 | 59 | 45 | 10 | 13 | 61 | 0 | 1 | 1 | 23 | 20 | C |
| RP | Minaya, J.Minaya, Juan >> | 30 | 2021 | R | 81 | 2 | 1 | 2.48 | .266 | .310 | 1.18 | 6.1 | 4.5 | 9.7 | 40 | 27 | 4 | 20 | 43 | 0 | 0 | 3 | 27 | 20 | C |
| SP | Dobnak, R.Dobnak, Randy >> | 26 | 2021 | R | 8 | 1 | 7 | 7.64 | .328 | .370 | 1.56 | 11.9 | 2.2 | 4.9 | 50 | 66 | 11 | 12 | 27 | 0 | 1 | 2 | 65 | 15 | C |
| SP | Pineda, M.Pineda, Michael >> | 32 | 2021 | R | 49 | 9 | 8 | 3.62 | .286 | .320 | 1.24 | 9.4 | 1.7 | 7.3 | 109 | 114 | 17 | 21 | 88 | 0 | 0 | 1 | 88 | 17 | C |
| RP | Stashak, C.Stashak, Cody >> | 27 | 2021 | R | 23 | 0 | 0 | 6.89 | .321 | .390 | 1.73 | 9.6 | 6.0 | 15.6 | 15 | 16 | 2 | 10 | 26 | 0 | 0 | 1 | 23 | 36 | C |
| RP | Robles, H.Robles, Hansel >> | 30 | 2021 | R | 57 | 3 | 5 | 4.43 | .304 | .340 | 1.38 | 7.6 | 4.8 | 9.9 | 69 | 58 | 8 | 37 | 76 | 0 | 14 | 4 | 23 | 20 | C |
| RP | Coulombe, D.Coulombe, Daniel >> | 31 | 2021 | L | 50 | 3 | 2 | 3.67 | .273 | .320 | 1.24 | 9.3 | 1.9 | 8.7 | 34 | 35 | 5 | 7 | 33 | 0 | 0 | 0 | 24 | 21 | C |