| SP | Peralta, F.Peralta, Freddy >> | 25 | 2021 | R | 98 | 10 | 5 | 2.81 | .241 | .270 | 0.97 | 5.3 | 3.5 | 12.2 | 144 | 84 | 14 | 56 | 195 | 1 | 0 | 4 | 91 | 22 | C |
| SP | Anderson, B.Anderson, Brett >> | 33 | 2021 | L | 31 | 4 | 9 | 4.22 | .304 | .340 | 1.35 | 9.6 | 2.6 | 5.4 | 96 | 102 | 11 | 28 | 58 | 0 | 0 | 0 | 72 | 15 | C |
| RP | Gustave, J.Gustave, Jandel >> | 28 | 2021 | R | 70 | 1 | 2 | 3.44 | .238 | .300 | 1.11 | 7.5 | 2.5 | 6.5 | 18 | 15 | 2 | 5 | 13 | 0 | 0 | 2 | 26 | 16 | C |
| RP | Feyereisen, J.Feyereisen, J.P. >> | 28 | 2021 | R | 75 | 4 | 4 | 2.73 | .279 | .320 | 1.23 | 5.8 | 5.3 | 8.5 | 56 | 36 | 5 | 33 | 53 | 0 | 3 | 3 | 23 | 18 | C |
| RP | Cousins, J.Cousins, Jake >> | 26 | 2021 | R | 90 | 1 | 0 | 2.70 | .259 | .310 | 1.17 | 4.8 | 5.7 | 13.2 | 30 | 16 | 3 | 19 | 44 | 0 | 0 | 2 | 23 | 24 | C |
| RP | Boxberger, B.Boxberger, Brad >> | 33 | 2021 | R | 91 | 5 | 4 | 3.34 | .255 | .290 | 1.08 | 6.2 | 3.5 | 11.7 | 64 | 44 | 8 | 25 | 83 | 0 | 4 | 3 | 23 | 21 | C |
| RP | Hader, J.Hader, Josh >> | 27 | 2021 | L | 100 | 4 | 2 | 1.23 | .210 | .250 | 0.84 | 3.9 | 3.7 | 15.8 | 58 | 25 | 3 | 24 | 102 | 0 | 34 | 3 | 23 | 27 | C |
| RP | Curtiss, J.Curtiss, John >> | 28 | 2021 | R | 58 | 3 | 1 | 3.45 | .276 | .320 | 1.23 | 8.6 | 2.5 | 9.0 | 44 | 42 | 6 | 12 | 44 | 0 | 0 | 1 | 23 | 21 | C |
| RP | Strickland, H.Strickland, Hunter >> | 32 | 2021 | R | 73 | 3 | 2 | 2.61 | .270 | .310 | 1.17 | 7.1 | 3.4 | 9.0 | 58 | 46 | 8 | 22 | 58 | 0 | 0 | 3 | 23 | 19 | C |
| SP | Burnes, C.Burnes, Corbin >> | 26 | 2021 | R | 97 | 11 | 5 | 2.43 | .235 | .270 | 0.94 | 6.6 | 1.8 | 12.6 | 167 | 123 | 7 | 34 | 234 | 0 | 0 | 5 | 105 | 23 | C |
| RP | Ashby, A.Ashby, Aaron >> | 23 | 2021 | R | 74 | 3 | 2 | 4.55 | .264 | .310 | 1.19 | 7.3 | 3.5 | 11.3 | 31 | 25 | 4 | 12 | 39 | 0 | 1 | 1 | 45 | 23 | C |
| RP | Sanchez, M.Sanchez, Miguel >> | 27 | 2021 | R | 22 | 2 | 1 | 4.15 | .318 | .370 | 1.58 | 9.3 | 4.8 | 8.0 | 26 | 27 | 4 | 14 | 23 | 0 | 0 | 2 | 23 | 21 | C |
| SP | Woodruff, B.Woodruff, Brandon >> | 28 | 2021 | R | 96 | 9 | 10 | 2.56 | .240 | .270 | 0.97 | 6.5 | 2.2 | 10.6 | 179 | 130 | 18 | 43 | 211 | 0 | 0 | 2 | 105 | 21 | C |
| RP | Richards, T.Richards, Trevor >> | 28 | 2021 | R | 97 | 7 | 2 | 3.50 | .235 | .270 | 0.97 | 5.6 | 3.1 | 11.0 | 64 | 40 | 12 | 22 | 78 | 0 | 1 | 8 | 25 | 21 | C |
| RP | Williams, D.Williams, Devin >> | 26 | 2021 | R | 86 | 8 | 2 | 2.50 | .271 | .310 | 1.19 | 6.0 | 4.7 | 14.5 | 54 | 36 | 5 | 28 | 87 | 0 | 3 | 2 | 23 | 24 | C |
| RP | Norris, D.Norris, Daniel >> | 28 | 2021 | L | 34 | 2 | 3 | 6.16 | .320 | .360 | 1.49 | 8.7 | 4.7 | 9.2 | 57 | 55 | 9 | 30 | 58 | 0 | 1 | 5 | 23 | 19 | C |
| RP | Perdomo, A.Perdomo, Angel >> | 27 | 2021 | L | 48 | 1 | 0 | 6.35 | .315 | .380 | 1.65 | 6.4 | 8.5 | 14.8 | 17 | 12 | 4 | 16 | 28 | 0 | 0 | 1 | 23 | 38 | C |
| RP | Yardley, E.Yardley, Eric >> | 30 | 2021 | R | 2 | 0 | 0 | 6.75 | .347 | .410 | 1.89 | 12.0 | 5.0 | 2.5 | 18 | 24 | 3 | 10 | 5 | 0 | 0 | 1 | 23 | 12 | C |
| RP | Lindblom, J.Lindblom, Josh >> | 34 | 2021 | R | 5 | 0 | 0 | 9.72 | .363 | .440 | 2.06 | 12.9 | 5.6 | 9.6 | 16 | 23 | 5 | 10 | 17 | 0 | 0 | 3 | 38 | 27 | C |
| RP | Rasmussen, D.Rasmussen, Drew >> | 25 | 2021 | R | 83 | 4 | 1 | 2.84 | .256 | .290 | 1.08 | 6.8 | 3.0 | 8.6 | 76 | 57 | 5 | 25 | 73 | 0 | 1 | 4 | 41 | 19 | C |
| RP | Suter, B.Suter, Brent >> | 31 | 2021 | L | 45 | 12 | 5 | 3.07 | .295 | .330 | 1.32 | 8.9 | 3.0 | 8.5 | 73 | 72 | 9 | 24 | 69 | 0 | 1 | 1 | 24 | 18 | C |
| RP | Milner, H.Milner, Hoby >> | 30 | 2021 | L | 21 | 0 | 0 | 5.40 | .311 | .370 | 1.57 | 12.9 | 1.3 | 12.9 | 21 | 30 | 8 | 3 | 30 | 0 | 0 | 0 | 23 | 25 | C |
| SP | Houser, A.Houser, Adrian >> | 28 | 2021 | R | 58 | 10 | 6 | 3.22 | .294 | .330 | 1.28 | 7.5 | 4.1 | 6.7 | 142 | 118 | 12 | 64 | 105 | 1 | 0 | 9 | 90 | 17 | C |
| SP | Lauer, E.Lauer, Eric >> | 26 | 2021 | L | 83 | 7 | 5 | 3.19 | .271 | .300 | 1.14 | 7.2 | 3.1 | 8.9 | 118 | 94 | 16 | 41 | 117 | 0 | 0 | 2 | 88 | 19 | C |