| RP | McHugh, C.McHugh, Collin >> | 34 | 2021 | R | 86 | 6 | 1 | 1.55 | .229 | .290 | 0.94 | 6.8 | 1.7 | 10.4 | 64 | 48 | 3 | 12 | 74 | 0 | 1 | 2 | 33 | +2 | C |
| RP | Kittredge, A.Kittredge, Andrew >> | 31 | 2021 | R | 79 | 9 | 3 | 1.88 | .239 | .300 | 0.99 | 7.0 | 1.9 | 9.8 | 71 | 55 | 7 | 15 | 77 | 0 | 8 | 5 | 25 | +2.4 | C |
| RP | Feyereisen, J.Feyereisen, J.P. >> | 28 | 2021 | R | 60 | 4 | 4 | 2.73 | .279 | .340 | 1.23 | 5.8 | 5.3 | 8.5 | 56 | 36 | 5 | 33 | 53 | 0 | 3 | 3 | 23 | +0.9 | C |
| SP | McClanahan, S.McClanahan, Shane >> | 24 | 2021 | L | 37 | 10 | 6 | 3.43 | .293 | .350 | 1.28 | 8.8 | 2.7 | 10.3 | 123 | 120 | 14 | 37 | 141 | 0 | 0 | 9 | 88 | +1.8 | C |
| RP | Armstrong, S.Armstrong, Shawn >> | 30 | 2021 | R | 17 | 1 | 0 | 6.75 | .314 | .380 | 1.50 | 9.8 | 3.8 | 11.0 | 36 | 39 | 10 | 15 | 44 | 0 | 0 | 0 | 24 | -0.6 | C |
| RP | Head, L.Head, Louis >> | 31 | 2021 | R | 90 | 2 | 0 | 2.31 | .207 | .270 | 0.86 | 5.4 | 2.3 | 8.2 | 35 | 21 | 2 | 9 | 32 | 0 | 0 | 1 | 26 | +0.6 | C |
| SP | Hill, R.Hill, Rich >> | 41 | 2021 | L | 55 | 7 | 8 | 3.86 | .284 | .340 | 1.22 | 7.8 | 3.1 | 8.5 | 158 | 137 | 21 | 55 | 150 | 0 | 0 | 3 | 88 | +1.6 | C |
| RP | Strickland, H.Strickland, Hunter >> | 32 | 2021 | R | 55 | 3 | 2 | 2.61 | .270 | .330 | 1.17 | 7.1 | 3.4 | 9.0 | 58 | 46 | 8 | 22 | 58 | 0 | 0 | 3 | 23 | +0.9 | C |
| SP | Fleming, J.Fleming, Josh >> | 25 | 2021 | L | 18 | 10 | 8 | 5.09 | .305 | .360 | 1.36 | 9.5 | 2.7 | 5.6 | 104 | 110 | 11 | 31 | 65 | 0 | 1 | 0 | 72 | -0.6 | C |
| SP | Wacha, M.Wacha, Michael >> | 29 | 2021 | R | 26 | 3 | 5 | 5.05 | .299 | .350 | 1.31 | 9.6 | 2.3 | 8.8 | 124 | 132 | 23 | 31 | 121 | 0 | 0 | 5 | 77 | -0.5 | C |
| SP | Patino, L.Patino, Luis >> | 21 | 2021 | R | 41 | 5 | 3 | 4.31 | .289 | .350 | 1.27 | 8.1 | 3.4 | 8.6 | 77 | 69 | 12 | 29 | 74 | 0 | 0 | 7 | 73 | +0.2 | C |
| RP | Wisler, M.Wisler, Matt >> | 28 | 2021 | R | 66 | 3 | 5 | 3.70 | .252 | .310 | 1.08 | 7.7 | 2.1 | 11.6 | 48 | 41 | 6 | 11 | 62 | 0 | 1 | 1 | 23 | +0.1 | C |
| RP | Rasmussen, D.Rasmussen, Drew >> | 25 | 2021 | R | 73 | 4 | 1 | 2.84 | .256 | .310 | 1.08 | 6.8 | 3.0 | 8.6 | 76 | 57 | 5 | 25 | 73 | 0 | 1 | 4 | 41 | +1.7 | C |
| SP | Glasnow, T.Glasnow, Tyler >> | 27 | 2021 | R | 98 | 5 | 2 | 2.66 | .230 | .290 | 0.93 | 5.6 | 2.8 | 12.6 | 88 | 55 | 10 | 27 | 123 | 0 | 0 | 8 | 111 | +2.4 | C |
| SP | Yarbrough, R.Yarbrough, Ryan >> | 29 | 2021 | L | 36 | 9 | 7 | 5.11 | .286 | .340 | 1.23 | 9.5 | 1.6 | 6.8 | 155 | 163 | 25 | 27 | 117 | 1 | 0 | 1 | 92 | -1 | C |
| RP | Thompson, R.Thompson, Ryan >> | 29 | 2021 | R | 78 | 3 | 2 | 2.38 | .238 | .310 | 1.03 | 6.9 | 2.4 | 9.8 | 34 | 26 | 3 | 9 | 37 | 0 | 0 | 1 | 23 | +0.8 | C |
| RP | Richards, T.Richards, Trevor >> | 28 | 2021 | R | 89 | 7 | 2 | 3.50 | .235 | .290 | 0.97 | 5.6 | 3.1 | 11.0 | 64 | 40 | 12 | 22 | 78 | 0 | 1 | 8 | 25 | +0.9 | C |
| RP | Springs, J.Springs, Jeffrey >> | 28 | 2021 | L | 68 | 5 | 1 | 3.43 | .257 | .320 | 1.11 | 7.2 | 2.9 | 12.9 | 44 | 35 | 9 | 14 | 63 | 0 | 2 | 3 | 23 | +0.2 | C |
| RP | Chargois, J.Chargois, J.T. >> | 30 | 2021 | R | 75 | 6 | 1 | 2.52 | .256 | .320 | 1.09 | 6.5 | 3.4 | 9.0 | 53 | 38 | 5 | 20 | 53 | 0 | 0 | 2 | 23 | +1.5 | C |
| RP | Castillo, D.Castillo, Diego >> | 27 | 2021 | R | 87 | 5 | 5 | 2.78 | .237 | .300 | 0.98 | 6.2 | 2.6 | 11.6 | 58 | 40 | 9 | 17 | 75 | 0 | 16 | 2 | 23 | +1.2 | C |
| RP | Fairbanks, P.Fairbanks, Peter >> | 27 | 2021 | R | 24 | 3 | 6 | 3.59 | .310 | .380 | 1.45 | 8.6 | 4.5 | 12.0 | 42 | 40 | 2 | 21 | 56 | 0 | 5 | 3 | 23 | +0.1 | C |