| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 20 | 20 | 7 | 6 | 3.04 | .265 | 1.05 | 6.7 | 2.8 | 7.9 | 142.1 | 105 | 55 | 48 | 18 | 44 | 124 | 2 | 0 | 0 | 1 | 14 | 5 | 2 | 3.94 |
| SP | Maddux, G.Maddux, Greg † # >> | 29 | 1995 | R | 89 | 19 | 19 | 12 | 3 | 3.54 | .268 | 1.08 | 7.8 | 1.9 | 5.5 | 145.0 | 125 | 61 | 57 | 19 | 31 | 88 | 4 | 0 | 0 | 1 | 11 | 3 | 1 | 4.19 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 18 | 18 | 4 | 10 | 5.09 | .325 | 1.43 | 9.1 | 3.8 | 5.3 | 115.0 | 116 | 76 | 65 | 12 | 48 | 68 | 3 | 0 | 0 | 1 | 6 | 2 | 2 | 4.48 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 60 | 18 | 18 | 10 | 5 | 3.62 | .293 | 1.22 | 7.3 | 3.8 | 4.5 | 121.2 | 98 | 55 | 49 | 12 | 51 | 60 | 1 | 0 | 0 | 0 | 10 | 2 | 3 | 4.61 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 18 | 18 | 7 | 8 | 4.29 | .323 | 1.43 | 8.3 | 4.6 | 3.0 | 115.1 | 106 | 61 | 55 | 9 | 59 | 38 | 1 | 0 | 0 | 0 | 10 | 0 | 4 | 4.90 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 39 | 0 | 2 | 6 | 2.61 | .275 | 1.11 | 8.1 | 2.0 | 7.2 | 41.1 | 37 | 15 | 12 | 6 | 9 | 33 | 0 | 23 | 2 | 0 | 0 | 1 | 1 | 4.02 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 39 | 0 | 2 | 2 | 2.74 | .220 | 0.85 | 5.3 | 2.3 | 10.2 | 46.0 | 27 | 16 | 14 | 3 | 12 | 52 | 0 | 4 | 1 | 0 | 0 | 0 | 5 | 2.37 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 25 | 0 | 3 | 0 | 3.86 | .307 | 1.33 | 10.6 | 1.6 | 8.6 | 23.1 | 27 | 11 | 10 | 4 | 4 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.87 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 13 | 0 | 0 | 0 | 4.32 | .296 | 1.26 | 7.3 | 4.5 | 5.1 | 16.2 | 13 | 8 | 8 | 4 | 8 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.63 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 10 | 0 | 1 | 0 | 4.13 | .298 | 1.27 | 8.8 | 2.6 | 5.3 | 48.0 | 47 | 33 | 22 | 7 | 14 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.60 |