| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 31 | 31 | 20 | 8 | 3.59 | .282 | 1.15 | 7.7 | 2.8 | 6.9 | 215.2 | 183 | 90 | 86 | 20 | 66 | 166 | 12 | 0 | 0 | 1 | 21 | 5 | 6 | 3.66 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 30 | 30 | 16 | 9 | 3.85 | .307 | 1.32 | 7.9 | 4.0 | 5.4 | 215.0 | 188 | 100 | 92 | 26 | 96 | 130 | 2 | 0 | 0 | 1 | 18 | 2 | 2 | 4.73 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 28 | 28 | 9 | 8 | 3.66 | .277 | 1.11 | 8.3 | 1.7 | 8.0 | 167.0 | 154 | 69 | 68 | 23 | 31 | 148 | 3 | 0 | 0 | 1 | 17 | 7 | 3 | 3.70 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 28 | 27 | 6 | 9 | 5.17 | .327 | 1.44 | 9.2 | 3.8 | 6.2 | 148.0 | 151 | 92 | 85 | 19 | 62 | 102 | 1 | 0 | 0 | 1 | 12 | 3 | 1 | 4.61 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 75 | 0 | 7 | 6 | 3.35 | .285 | 1.17 | 7.2 | 3.4 | 8.4 | 91.1 | 73 | 37 | 34 | 13 | 34 | 85 | 0 | 9 | 5 | 0 | 0 | 2 | 4 | 4.18 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 52 | 0 | 4 | 3 | 3.53 | .313 | 1.36 | 8.5 | 3.9 | 9.8 | 58.2 | 55 | 23 | 23 | 7 | 25 | 63 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 3.69 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 62 | 0 | 3 | 8 | 3.72 | .308 | 1.32 | 8.1 | 3.9 | 9.4 | 72.2 | 65 | 30 | 30 | 10 | 31 | 75 | 0 | 8 | 3 | 0 | 0 | 1 | 1 | 4.06 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 33 | 0 | 4 | 2 | 3.35 | .281 | 1.14 | 6.6 | 3.7 | 7.6 | 53.2 | 39 | 20 | 20 | 5 | 22 | 45 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3.89 |