| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 20 | 20 | 7 | 2 | 2.79 | .250 | 0.98 | 6.9 | 1.9 | 8.7 | 135.1 | 104 | 44 | 42 | 13 | 29 | 131 | 0 | 0 | 0 | 0 | 15 | 2 | 0 | 3.00 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 20 | 20 | 9 | 3 | 5.16 | .304 | 1.30 | 9.4 | 2.4 | 7.0 | 111.2 | 116 | 67 | 64 | 17 | 29 | 86 | 1 | 0 | 0 | 1 | 8 | 1 | 3 | 4.25 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 18 | 18 | 10 | 2 | 2.89 | .258 | 0.99 | 7.4 | 1.6 | 4.7 | 131.0 | 107 | 45 | 42 | 14 | 23 | 69 | 6 | 0 | 0 | 0 | 12 | 7 | 4 | 4.02 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 18 | 18 | 5 | 8 | 6.22 | .346 | 1.56 | 9.4 | 4.7 | 7.9 | 88.1 | 92 | 64 | 61 | 16 | 46 | 77 | 1 | 0 | 0 | 0 | 5 | 2 | 1 | 5.25 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 51 | 0 | 3 | 1 | 2.65 | .297 | 1.21 | 5.5 | 5.5 | 11.2 | 57.2 | 35 | 17 | 17 | 2 | 35 | 71 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 2.96 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 46 | 0 | 7 | 2 | 1.98 | .237 | 0.90 | 5.0 | 3.1 | 5.6 | 59.0 | 33 | 16 | 13 | 6 | 20 | 37 | 0 | 4 | 0 | 0 | 0 | 2 | 0 | 4.19 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 31 | 0 | 1 | 2 | 2.50 | .303 | 1.31 | 7.3 | 4.5 | 7.5 | 36.0 | 29 | 10 | 10 | 2 | 18 | 30 | 0 | 0 | 1 | 0 | 0 | 0 | 6 | 3.56 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 25 | 0 | 1 | 2 | 4.65 | .256 | 1.03 | 7.5 | 1.7 | 7.0 | 31.0 | 26 | 16 | 16 | 8 | 6 | 24 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 5.39 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 14 | 0 | 2 | 5 | 5.40 | .329 | 1.47 | 10.5 | 2.8 | 6.9 | 48.1 | 56 | 29 | 29 | 9 | 15 | 37 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 4.83 |