| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 11 | 11 | 2 | 4 | 3.52 | .312 | 1.31 | 7.9 | 4.0 | 8.5 | 79.1 | 69 | 32 | 31 | 4 | 35 | 75 | 2 | 0 | 0 | 1 | 7 | 4 | 5 | 3.24 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 11 | 11 | 4 | 3 | 4.20 | .292 | 1.24 | 9.2 | 1.9 | 3.9 | 79.1 | 81 | 41 | 37 | 9 | 17 | 34 | 3 | 0 | 0 | 0 | 5 | 0 | 5 | 4.27 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 11 | 11 | 5 | 4 | 3.24 | .306 | 1.29 | 8.0 | 3.6 | 4.8 | 75.0 | 67 | 28 | 27 | 1 | 30 | 40 | 3 | 0 | 0 | 3 | 8 | 2 | 3 | 3.39 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 11 | 10 | 4 | 3 | 3.15 | .302 | 1.28 | 6.8 | 4.8 | 4.7 | 60.0 | 45 | 23 | 21 | 3 | 32 | 31 | 0 | 0 | 0 | 0 | 7 | 1 | 3 | 4.27 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 24 | 0 | 3 | 1 | 4.05 | .306 | 1.26 | 9.0 | 2.5 | 10.4 | 33.1 | 33 | 15 | 15 | 4 | 9 | 38 | 0 | 2 | 4 | 0 | 0 | 2 | 2 | 3.27 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 23 | 0 | 3 | 5 | 3.30 | .256 | 1.03 | 8.1 | 1.2 | 6.6 | 30.0 | 27 | 14 | 11 | 7 | 4 | 22 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.97 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 69 | 21 | 0 | 1 | 1 | 4.50 | .298 | 1.23 | 7.0 | 4.1 | 5.3 | 22.0 | 17 | 11 | 11 | 3 | 10 | 13 | 0 | 5 | 2 | 0 | 0 | 1 | 0 | 5.09 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 61 | 2 | 1 | 1 | 0 | 5.40 | .355 | 1.65 | 15.0 | 1.5 | 3.0 | 6.2 | 10 | 4 | 4 | 2 | 1 | 2 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 7.17 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 4 | 0 | 1 | 0 | 0.00 | .125 | 0.43 | 3.9 | 0.0 | 7.7 | 7.0 | 3 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.29 |