| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 29 | 29 | 11 | 13 | 4.10 | .298 | 1.26 | 9.1 | 2.2 | 4.1 | 200.0 | 202 | 97 | 91 | 27 | 49 | 92 | 9 | 0 | 0 | 3 | 15 | 4 | 5 | 4.63 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 68 | 29 | 29 | 8 | 13 | 5.99 | .342 | 1.51 | 10.9 | 2.8 | 7.8 | 178.2 | 215 | 124 | 119 | 27 | 55 | 155 | 1 | 0 | 0 | 0 | 9 | 8 | 5 | 4.29 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 66 | 29 | 29 | 10 | 12 | 4.65 | .308 | 1.31 | 8.9 | 2.9 | 5.7 | 187.2 | 185 | 104 | 97 | 29 | 60 | 119 | 6 | 0 | 0 | 3 | 13 | 5 | 3 | 4.79 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 28 | 28 | 6 | 16 | 5.64 | .356 | 1.64 | 10.7 | 4.2 | 4.9 | 183.2 | 217 | 127 | 115 | 24 | 85 | 100 | 7 | 0 | 0 | 1 | 10 | 3 | 9 | 5.05 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 69 | 0 | 6 | 6 | 4.62 | .275 | 1.12 | 8.9 | 1.2 | 7.3 | 87.2 | 86 | 46 | 45 | 13 | 12 | 71 | 0 | 3 | 5 | 0 | 0 | 2 | 1 | 3.79 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 55 | 0 | 1 | 6 | 3.50 | .301 | 1.23 | 7.9 | 3.2 | 7.5 | 64.1 | 56 | 29 | 25 | 7 | 23 | 53 | 0 | 4 | 2 | 0 | 0 | 4 | 2 | 4.03 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 61 | 41 | 0 | 3 | 3 | 3.47 | .301 | 1.29 | 8.7 | 3.1 | 8.7 | 59.2 | 57 | 25 | 23 | 5 | 20 | 57 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 3.19 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 51 | 10 | 0 | 0 | 1 | 8.47 | .427 | 2.24 | 13.8 | 6.4 | 6.9 | 17.0 | 26 | 16 | 16 | 4 | 12 | 13 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 6.65 |