| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 30 | 30 | 18 | 8 | 3.07 | .259 | 1.03 | 7.2 | 2.1 | 10.2 | 223.0 | 178 | 77 | 76 | 20 | 51 | 252 | 6 | 0 | 0 | 3 | 22 | 5 | 3 | 2.66 |
| SP | McClanahan, S.McClanahan, Shane # >> | 25 | 2022 | L | 89 | 29 | 29 | 19 | 7 | 3.81 | .282 | 1.15 | 7.7 | 2.7 | 9.3 | 172.2 | 147 | 74 | 73 | 19 | 51 | 177 | 1 | 0 | 0 | 0 | 20 | 5 | 6 | 3.35 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 79 | 29 | 29 | 7 | 14 | 5.35 | .325 | 1.40 | 9.0 | 3.6 | 6.1 | 185.0 | 186 | 116 | 110 | 30 | 73 | 126 | 7 | 0 | 0 | 1 | 11 | 8 | 15 | 5.06 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 29 | 29 | 5 | 8 | 5.65 | .327 | 1.41 | 9.3 | 3.4 | 8.7 | 124.1 | 128 | 78 | 78 | 29 | 47 | 120 | 0 | 0 | 0 | 0 | 2 | 6 | 4 | 5.39 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 58 | 0 | 6 | 3 | 1.23 | .201 | 0.73 | 4.4 | 2.1 | 8.9 | 73.0 | 36 | 10 | 10 | 5 | 17 | 72 | 0 | 35 | 2 | 0 | 0 | 2 | 1 | 2.70 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 63 | 0 | 4 | 2 | 3.09 | .283 | 1.17 | 6.8 | 3.7 | 8.1 | 70.0 | 53 | 25 | 24 | 9 | 29 | 63 | 0 | 1 | 6 | 0 | 0 | 1 | 0 | 4.16 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 62 | 0 | 2 | 2 | 3.84 | .294 | 1.21 | 7.5 | 3.5 | 10.1 | 72.2 | 60 | 32 | 31 | 9 | 28 | 81 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 3.67 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 51 | 0 | 3 | 0 | 3.67 | .296 | 1.20 | 7.2 | 3.7 | 10.3 | 54.0 | 43 | 22 | 22 | 5 | 22 | 62 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 3.30 |
| RP | Clippard, T.Clippard, Tyler # >> | 26 | 2011 | R | 78 | 45 | 0 | 4 | 1 | 3.67 | .293 | 1.22 | 6.8 | 4.2 | 8.3 | 49.0 | 37 | 21 | 20 | 9 | 23 | 45 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 5.02 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 35 | 0 | 3 | 1 | 1.91 | .201 | 0.76 | 3.6 | 3.2 | 9.0 | 42.1 | 17 | 9 | 9 | 4 | 15 | 42 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.31 |