| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 34 | 34 | 9 | 13 | 4.52 | .308 | 1.32 | 8.5 | 3.3 | 8.9 | 225.0 | 213 | 114 | 113 | 34 | 83 | 222 | 1 | 0 | 0 | 0 | 18 | 4 | 5 | 4.15 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 87 | 32 | 32 | 9 | 14 | 4.47 | .315 | 1.36 | 9.2 | 3.1 | 9.8 | 205.1 | 209 | 110 | 102 | 31 | 71 | 223 | 1 | 0 | 0 | 0 | 18 | 3 | 7 | 3.87 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 32 | 32 | 11 | 14 | 4.72 | .332 | 1.47 | 9.8 | 3.4 | 8.5 | 208.0 | 227 | 114 | 109 | 23 | 79 | 196 | 1 | 0 | 0 | 0 | 16 | 4 | 9 | 3.75 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 73 | 31 | 31 | 13 | 10 | 4.17 | .331 | 1.44 | 9.6 | 3.4 | 6.8 | 211.1 | 224 | 103 | 98 | 36 | 80 | 159 | 7 | 0 | 0 | 2 | 14 | 9 | 2 | 4.98 |
| CL | Saito, T.Saito, Takashi † >> | 37 | 2007 | R | 90 | 68 | 0 | 4 | 7 | 4.28 | .295 | 1.23 | 8.7 | 2.3 | 8.7 | 69.1 | 67 | 35 | 33 | 12 | 18 | 67 | 0 | 32 | 6 | 0 | 0 | 2 | 0 | 4.19 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 94 | 78 | 0 | 7 | 3 | 2.74 | .264 | 1.07 | 6.5 | 3.1 | 11.7 | 92.0 | 66 | 31 | 28 | 9 | 32 | 120 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 2.74 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 81 | 63 | 0 | 4 | 3 | 2.84 | .274 | 1.13 | 5.8 | 4.4 | 10.9 | 76.0 | 49 | 24 | 24 | 7 | 37 | 92 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 3.24 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 49 | 0 | 4 | 2 | 4.48 | .290 | 1.19 | 7.8 | 3.0 | 8.3 | 60.1 | 52 | 30 | 30 | 10 | 20 | 55 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 4.43 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 66 | 31 | 0 | 2 | 1 | 2.50 | .270 | 1.11 | 5.5 | 4.6 | 8.3 | 39.2 | 24 | 11 | 11 | 3 | 20 | 36 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.69 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 31 | 0 | 2 | 0 | 1.59 | .244 | 0.94 | 6.4 | 2.1 | 9.3 | 34.0 | 24 | 8 | 6 | 3 | 8 | 35 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.88 |