| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 94 | 31 | 31 | 11 | 14 | 3.86 | .299 | 1.24 | 8.0 | 3.2 | 7.3 | 193.2 | 172 | 97 | 83 | 25 | 69 | 156 | 3 | 0 | 0 | 0 | 19 | 7 | 8 | 4.25 |
| SP | Buehrle, M.Buehrle, Mark >> | 31 | 2001 | L | 93 | 31 | 31 | 15 | 12 | 2.66 | .252 | 0.96 | 6.9 | 1.7 | 6.1 | 240.0 | 185 | 82 | 71 | 25 | 45 | 162 | 14 | 0 | 0 | 2 | 24 | 12 | 2 | 3.72 |
| SP | McCarthy, B.McCarthy, Brandon # >> | 27 | 2005 | R | 93 | 30 | 30 | 16 | 7 | 3.42 | .270 | 1.08 | 7.8 | 1.9 | 7.5 | 215.2 | 187 | 91 | 82 | 28 | 46 | 178 | 3 | 0 | 0 | 0 | 24 | 6 | 3 | 3.76 |
| SP | Volquez, E.Volquez, Edinson >> | 27 | 2008 | R | 76 | 28 | 28 | 9 | 8 | 4.45 | .319 | 1.37 | 8.0 | 4.5 | 8.5 | 163.2 | 144 | 85 | 81 | 18 | 81 | 154 | 0 | 0 | 0 | 0 | 17 | 5 | 1 | 4.13 |
| RP | Boyer, B.Boyer, Blaine >> | 29 | 2005 | R | 95 | 46 | 0 | 7 | 3 | 2.54 | .271 | 1.10 | 5.6 | 4.4 | 6.7 | 63.2 | 39 | 21 | 18 | 4 | 31 | 47 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.86 |
| RP | Beltran, F.Beltran, Francis >> | 31 | 2004 | R | 86 | 11 | 0 | 0 | 0 | 3.31 | .300 | 1.29 | 5.6 | 6.2 | 5.1 | 16.1 | 10 | 6 | 6 | 1 | 11 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.75 |
| RP | Fruto, E.Fruto, Emiliano >> | 26 | 2006 | R | 82 | 13 | 0 | 3 | 0 | 2.41 | .211 | 0.75 | 5.0 | 2.0 | 9.0 | 18.2 | 10 | 6 | 5 | 1 | 4 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.56 |
| CL | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 99 | 56 | 0 | 0 | 2 | 2.58 | .256 | 1.03 | 5.4 | 4.0 | 9.5 | 52.1 | 31 | 16 | 15 | 3 | 23 | 55 | 0 | 50 | 5 | 0 | 0 | 0 | 0 | 2.96 |
| RP | Wright, W.Wright, Wesley >> | 25 | 2008 | L | 76 | 4 | 0 | 0 | 0 | 1.69 | .304 | 1.31 | 7.2 | 5.4 | 12.6 | 5.1 | 4 | 1 | 1 | 0 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |