| SP | Tejeda, R.Tejeda, Robinson >> | 28 | 2005 | R | 98 | 31 | 31 | 10 | 7 | 3.35 | .271 | 1.07 | 6.2 | 3.5 | 6.6 | 161.0 | 111 | 60 | 60 | 18 | 62 | 118 | 0 | 0 | 0 | 0 | 9 | 7 | 5 | 4.27 |
| SP | Zambrano, C.Zambrano, Carlos >> | 29 | 2005 | R | 94 | 31 | 31 | 9 | 15 | 3.83 | .286 | 1.16 | 8.0 | 2.5 | 7.2 | 211.2 | 187 | 96 | 90 | 34 | 58 | 168 | 5 | 0 | 0 | 0 | 16 | 9 | 2 | 4.45 |
| SP | Hamels, C.Hamels, Cole >> | 27 | 2006 | L | 90 | 31 | 31 | 10 | 12 | 3.47 | .282 | 1.16 | 7.8 | 2.6 | 9.2 | 202.1 | 176 | 79 | 78 | 26 | 59 | 207 | 3 | 0 | 0 | 0 | 21 | 3 | 7 | 3.54 |
| RP | Madson, R.Madson, Ryan # >> | 30 | 2005 | R | 74 | 73 | 0 | 2 | 5 | 5.02 | .305 | 1.28 | 8.6 | 2.9 | 6.8 | 95.0 | 91 | 58 | 53 | 19 | 31 | 72 | 0 | 1 | 2 | 0 | 0 | 3 | 6 | 5.16 |
| CL | Padilla, V.Padilla, Vicente # >> | 33 | 2000 | R | 72 | 53 | 0 | 2 | 5 | 4.38 | .321 | 1.42 | 9.4 | 3.5 | 8.3 | 49.1 | 51 | 25 | 24 | 9 | 19 | 45 | 0 | 29 | 10 | 0 | 0 | 0 | 2 | 4.71 |
| RP | Silva, C.Silva, Carlos >> | 31 | 2002 | R | 70 | 59 | 0 | 3 | 5 | 4.57 | .292 | 1.22 | 9.1 | 1.9 | 4.6 | 84.2 | 85 | 44 | 43 | 10 | 18 | 43 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.24 |
| RP | Bennett, J.Bennett, Jeff >> | 30 | 2004 | R | 68 | 33 | 0 | 2 | 4 | 3.12 | .261 | 1.06 | 6.7 | 2.9 | 6.1 | 43.1 | 32 | 15 | 15 | 4 | 14 | 29 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.84 |
| SP | Duckworth, B.Duckworth, Brandon >> | 34 | 2001 | R | 79 | 28 | 0 | 2 | 3 | 3.91 | .305 | 1.29 | 8.6 | 3.1 | 6.3 | 126.2 | 121 | 61 | 55 | 10 | 43 | 88 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 3.73 |
| RP | McClellan, K.McClellan, Kyle >> | 26 | 2010 | R | 71 | 15 | 0 | 1 | 0 | 2.25 | .304 | 1.25 | 9.0 | 2.3 | 6.8 | 16.0 | 16 | 6 | 4 | 3 | 4 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.88 |