| SP | Hernandez, L.Hernandez, Livan # >> | 35 | 1997 | R | 92 | 32 | 32 | 10 | 18 | 5.20 | .331 | 1.43 | 9.6 | 3.3 | 6.6 | 195.2 | 208 | 118 | 113 | 22 | 72 | 143 | 2 | 0 | 0 | 0 | 11 | 11 | 0 | 4.28 |
| SP | Blanton, J.Blanton, Joe # >> | 30 | 2005 | R | 83 | 33 | 33 | 10 | 14 | 4.58 | .309 | 1.30 | 8.5 | 3.2 | 6.7 | 200.1 | 189 | 109 | 102 | 29 | 72 | 148 | 1 | 0 | 0 | 0 | 16 | 8 | 3 | 4.61 |
| SP | Gabbard, K.Gabbard, Kason # >> | 28 | 2007 | L | 79 | 31 | 31 | 7 | 14 | 5.56 | .308 | 1.27 | 7.6 | 3.9 | 6.9 | 166.2 | 140 | 116 | 103 | 33 | 72 | 128 | 1 | 0 | 0 | 1 | 14 | 11 | 8 | 5.54 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 30 | 2006 | R | 99 | 39 | 0 | 0 | 2 | 3.41 | .260 | 1.03 | 7.1 | 2.2 | 9.2 | 37.0 | 29 | 14 | 14 | 7 | 9 | 38 | 0 | 31 | 3 | 0 | 0 | 1 | 0 | 4.22 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 28 | 2008 | R | 89 | 89 | 0 | 4 | 2 | 3.74 | .297 | 1.25 | 7.5 | 3.8 | 6.6 | 98.2 | 82 | 42 | 41 | 12 | 41 | 72 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 4.44 |
| RP | Aceves, A.Aceves, Alfredo # >> | 28 | 2009 | R | 77 | 54 | 0 | 4 | 7 | 4.84 | .331 | 1.47 | 10.8 | 2.6 | 6.8 | 70.2 | 84 | 40 | 38 | 16 | 20 | 53 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 5.36 |
| RP | Masterson, J.Masterson, Justin >> | 25 | 2008 | R | 76 | 39 | 0 | 5 | 1 | 5.44 | .341 | 1.53 | 10.6 | 3.3 | 6.5 | 46.1 | 54 | 28 | 28 | 9 | 17 | 33 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 5.28 |
| RP | Fossum, C.Fossum, Casey >> | 32 | 2002 | L | 70 | 95 | 0 | 4 | 3 | 2.85 | .255 | 1.01 | 7.1 | 2.1 | 8.3 | 113.2 | 89 | 38 | 36 | 11 | 26 | 104 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 3.17 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 30 | 2008 | R | 64 | 29 | 12 | 3 | 6 | 6.69 | .352 | 1.61 | 9.1 | 5.5 | 6.9 | 122.1 | 123 | 93 | 91 | 27 | 74 | 94 | 0 | 0 | 0 | 0 | 2 | 2 | 3 | 6.20 |