| SP | Blanton, J.Blanton, Joe >> | 27 | 2005 | R | 79 | 33 | 33 | 9 | 14 | 5.14 | .324 | 1.41 | 9.7 | 3.0 | 6.2 | 191.0 | 205 | 120 | 109 | 37 | 64 | 132 | 1 | 0 | 0 | 0 | 14 | 6 | 5 | 5.24 |
| SP | Colon, B.Colon, Bartolo # >> | 34 | 1999 | R | 61 | 29 | 29 | 6 | 14 | 5.05 | .339 | 1.51 | 9.6 | 4.0 | 6.3 | 164.0 | 175 | 108 | 92 | 28 | 72 | 115 | 1 | 0 | 0 | 1 | 12 | 5 | 5 | 5.23 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke # >> | 27 | 2007 | R | 54 | 32 | 19 | 5 | 13 | 5.58 | .344 | 1.54 | 10.3 | 3.6 | 6.8 | 113.0 | 129 | 72 | 70 | 22 | 45 | 85 | 0 | 2 | 1 | 0 | 8 | 4 | 3 | 5.33 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 27 | 2006 | R | 98 | 71 | 0 | 1 | 6 | 2.96 | .252 | 0.97 | 6.3 | 2.5 | 9.2 | 76.0 | 53 | 25 | 25 | 7 | 21 | 78 | 0 | 23 | 2 | 0 | 0 | 3 | 2 | 3.09 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 85 | 108 | 0 | 6 | 3 | 3.07 | .234 | 0.89 | 5.6 | 2.5 | 6.8 | 102.2 | 63 | 37 | 35 | 10 | 28 | 77 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | 3.68 |
| RP | Castillo, C.Castillo, Carlos >> | 32 | 1997 | R | 84 | 52 | 0 | 0 | 2 | 3.34 | .288 | 1.20 | 7.9 | 2.9 | 6.9 | 59.1 | 52 | 24 | 22 | 10 | 19 | 45 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.69 |
| RP | Padilla, J.Padilla, Juan >> | 30 | 2005 | R | 79 | 42 | 0 | 1 | 4 | 4.83 | .320 | 1.39 | 7.2 | 5.3 | 4.6 | 41.0 | 33 | 22 | 22 | 5 | 24 | 21 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.39 |
| RP | Fossum, C.Fossum, Casey >> | 29 | 2002 | L | 76 | 76 | 0 | 3 | 5 | 4.27 | .294 | 1.20 | 8.3 | 2.6 | 6.9 | 90.2 | 83 | 43 | 43 | 11 | 26 | 69 | 0 | 5 | 3 | 0 | 0 | 4 | 4 | 4.06 |
| RP | Wasdin, J.Wasdin, John >> | 35 | 1997 | R | 51 | 68 | 0 | 5 | 6 | 5.93 | .344 | 1.56 | 9.6 | 4.5 | 6.1 | 74.1 | 79 | 50 | 49 | 15 | 37 | 50 | 0 | 1 | 3 | 0 | 0 | 1 | 5 | 5.82 |