| SP | Johnson, R.Johnson, Randy $ >> | 38 | 2001 | L | 97 | 26 | 26 | 11 | 7 | 4.09 | .303 | 1.28 | 8.1 | 3.4 | 10.0 | 169.1 | 152 | 79 | 77 | 19 | 64 | 188 | 3 | 0 | 0 | 1 | 16 | 5 | 7 | 3.46 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 87 | 26 | 26 | 8 | 10 | 4.77 | .299 | 1.27 | 9.2 | 2.3 | 6.5 | 168.0 | 171 | 92 | 89 | 25 | 42 | 122 | 4 | 0 | 0 | 1 | 13 | 2 | 2 | 4.27 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 78 | 25 | 25 | 6 | 11 | 6.04 | .344 | 1.54 | 11.2 | 2.6 | 6.5 | 140.0 | 174 | 98 | 94 | 31 | 41 | 101 | 0 | 0 | 0 | 0 | 8 | 5 | 1 | 5.42 |
| SP | Prior, M.Prior, Mark # >> | 23 | 2003 | R | 69 | 25 | 25 | 10 | 6 | 5.45 | .326 | 1.44 | 10.1 | 2.9 | 9.6 | 158.2 | 177 | 99 | 96 | 34 | 51 | 168 | 1 | 0 | 0 | 1 | 10 | 2 | 2 | 4.68 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 50 | 0 | 8 | 3 | 2.70 | .259 | 1.05 | 5.6 | 3.9 | 11.0 | 53.1 | 33 | 17 | 16 | 3 | 23 | 65 | 0 | 27 | 7 | 0 | 0 | 0 | 1 | 2.58 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 42 | 0 | 2 | 2 | 3.83 | .314 | 1.35 | 9.9 | 2.3 | 10.1 | 40.0 | 44 | 20 | 17 | 6 | 10 | 45 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.53 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 44 | 0 | 1 | 0 | 2.78 | .292 | 1.21 | 6.8 | 4.2 | 7.2 | 45.1 | 34 | 20 | 14 | 3 | 21 | 36 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.73 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 50 | 0 | 5 | 1 | 3.04 | .281 | 1.15 | 7.4 | 3.1 | 11.9 | 50.1 | 41 | 17 | 17 | 9 | 17 | 66 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.78 |
| RP | Turnbow, D.Turnbow, Derrick >> | 27 | 2005 | R | 37 | 41 | 0 | 2 | 3 | 3.28 | .291 | 1.23 | 7.5 | 3.9 | 8.2 | 35.2 | 29 | 15 | 13 | 4 | 15 | 32 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 3.94 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 68 | 0 | 11 | 0 | 3.31 | .313 | 1.29 | 9.5 | 2.1 | 11.6 | 68.0 | 72 | 26 | 25 | 8 | 16 | 88 | 0 | 2 | 2 | 0 | 0 | 5 | 8 | 2.87 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 61 | 0 | 4 | 0 | 3.60 | .318 | 1.31 | 7.4 | 4.4 | 10.2 | 45.0 | 37 | 19 | 18 | 1 | 22 | 51 | 0 | 0 | 2 | 0 | 0 | 4 | 1 | 2.76 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 53 | 35 | 0 | 1 | 1 | 3.75 | .345 | 1.58 | 9.8 | 4.5 | 9.8 | 24.0 | 26 | 16 | 10 | 5 | 12 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.04 |