| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 100 | 26 | 26 | 11 | 8 | 4.19 | .293 | 1.21 | 8.5 | 2.4 | 9.0 | 189.0 | 179 | 96 | 88 | 30 | 50 | 190 | 8 | 0 | 0 | 2 | 14 | 6 | 3 | 3.94 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 26 | 26 | 7 | 9 | 5.45 | .332 | 1.49 | 9.2 | 4.2 | 9.1 | 145.1 | 149 | 91 | 88 | 22 | 67 | 147 | 0 | 0 | 0 | 0 | 12 | 1 | 3 | 4.35 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 79 | 25 | 25 | 10 | 5 | 5.62 | .342 | 1.48 | 9.4 | 4.0 | 6.7 | 113.2 | 118 | 71 | 71 | 17 | 50 | 84 | 0 | 0 | 0 | 0 | 4 | 9 | 1 | 5.04 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 25 | 24 | 12 | 4 | 4.23 | .305 | 1.27 | 9.1 | 2.3 | 6.0 | 142.2 | 144 | 72 | 67 | 26 | 37 | 94 | 0 | 0 | 0 | 0 | 14 | 7 | 0 | 4.99 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 50 | 0 | 8 | 6 | 3.79 | .279 | 1.16 | 9.0 | 1.5 | 10.2 | 59.1 | 59 | 27 | 25 | 8 | 10 | 67 | 0 | 24 | 4 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 63 | 0 | 2 | 4 | 4.15 | .300 | 1.25 | 6.0 | 5.3 | 9.7 | 69.1 | 46 | 32 | 32 | 10 | 41 | 74 | 0 | 0 | 3 | 0 | 0 | 2 | 4 | 4.61 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 75 | 0 | 1 | 2 | 5.00 | .332 | 1.47 | 10.0 | 3.2 | 5.2 | 45.0 | 50 | 26 | 25 | 10 | 16 | 26 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 5.87 |
| SP | Sabathia, C.Sabathia, CC >> | 28 | 2008 | L | 60 | 19 | 0 | 2 | 2 | 5.03 | .312 | 1.32 | 9.7 | 2.3 | 7.2 | 82.1 | 88 | 54 | 46 | 14 | 21 | 66 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 4.49 |