| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 7 | 7 | 2 | 1 | 2.16 | .265 | 1.08 | 6.0 | 3.8 | 7.1 | 33.1 | 22 | 14 | 8 | 2 | 14 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.48 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 76 | 7 | 7 | 4 | 3 | 4.50 | .310 | 1.30 | 7.8 | 3.9 | 7.6 | 46.0 | 40 | 23 | 23 | 9 | 20 | 39 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 5.28 |
| SP | Sabathia, C.Sabathia, CC >> | 28 | 2008 | L | 60 | 7 | 7 | 3 | 2 | 4.59 | .338 | 1.51 | 10.2 | 3.4 | 7.4 | 51.0 | 58 | 27 | 26 | 6 | 19 | 42 | 1 | 0 | 0 | 0 | 5 | 1 | 0 | 4.06 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 53 | 7 | 7 | 4 | 3 | 4.63 | .300 | 1.26 | 9.2 | 2.3 | 6.8 | 46.2 | 47 | 27 | 24 | 8 | 12 | 35 | 3 | 0 | 0 | 0 | 4 | 1 | 4 | 4.59 |
| SP | Verlander, J.Verlander, Justin # >> | 26 | 2009 | R | 42 | 7 | 7 | 4 | 3 | 5.47 | .299 | 1.28 | 9.4 | 2.2 | 8.4 | 49.1 | 51 | 31 | 30 | 9 | 12 | 46 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 4.24 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 17 | 0 | 0 | 0 | 1.74 | .253 | 0.97 | 5.4 | 3.6 | 6.8 | 20.2 | 12 | 4 | 4 | 0 | 8 | 15 | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 2.85 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 52 | 13 | 0 | 2 | 0 | 4.80 | .357 | 1.60 | 7.2 | 7.2 | 9.6 | 15.0 | 12 | 8 | 8 | 3 | 12 | 16 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 6.07 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 34 | 10 | 0 | 0 | 1 | 7.30 | .351 | 1.62 | 10.5 | 4.5 | 8.3 | 12.1 | 14 | 11 | 10 | 3 | 6 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.92 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 4 | 0 | 0 | 1 | 10.13 | .448 | 2.44 | 14.4 | 9.0 | 3.6 | 5.1 | 8 | 6 | 6 | 1 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.80 |