| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 10 | 10 | 6 | 3 | 3.42 | .292 | 1.24 | 8.8 | 2.5 | 10.0 | 73.2 | 71 | 28 | 28 | 8 | 20 | 81 | 1 | 0 | 0 | 1 | 7 | 0 | 1 | 3.03 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 10 | 10 | 2 | 6 | 4.18 | .292 | 1.21 | 7.2 | 3.8 | 8.6 | 64.2 | 51 | 31 | 30 | 9 | 27 | 61 | 2 | 0 | 0 | 1 | 6 | 2 | 1 | 4.28 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 9 | 9 | 0 | 5 | 9.31 | .380 | 1.82 | 13.3 | 3.2 | 4.5 | 48.1 | 71 | 58 | 50 | 13 | 17 | 24 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 6.65 |
| SP | Clement, M.Clement, Matt # >> | 28 | 2002 | R | 53 | 9 | 9 | 3 | 4 | 6.51 | .350 | 1.62 | 9.6 | 5.0 | 7.5 | 47.0 | 50 | 36 | 34 | 8 | 26 | 39 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 5.21 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 27 | 0 | 1 | 2 | 2.56 | .237 | 0.93 | 5.4 | 3.1 | 9.0 | 38.2 | 23 | 11 | 11 | 1 | 13 | 38 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 2.37 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 21 | 0 | 2 | 0 | 5.46 | .294 | 1.21 | 6.4 | 4.5 | 6.8 | 28.0 | 20 | 17 | 17 | 1 | 14 | 21 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 3.57 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 19 | 0 | 1 | 1 | 6.86 | .337 | 1.43 | 8.6 | 4.3 | 8.1 | 21.0 | 20 | 16 | 16 | 3 | 10 | 19 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 4.76 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 12 | 0 | 2 | 0 | 3.86 | .288 | 1.14 | 6.4 | 3.9 | 10.3 | 14.0 | 10 | 6 | 6 | 2 | 6 | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.07 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 15 | 0 | 1 | 0 | 4.95 | .326 | 1.40 | 10.8 | 1.8 | 7.7 | 20.0 | 24 | 12 | 11 | 7 | 4 | 17 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 6.60 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 52 | 7 | 0 | 0 | 1 | 10.50 | .345 | 1.58 | 11.3 | 3.0 | 2.3 | 12.0 | 15 | 14 | 14 | 6 | 4 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 10.00 |