| SP | Hernandez, F.Hernandez, Felix † >> | 19 | 2005 | R | 96 | 26 | 26 | 12 | 8 | 3.17 | .275 | 1.12 | 7.2 | 2.9 | 7.2 | 179.0 | 144 | 76 | 63 | 25 | 57 | 144 | 6 | 0 | 0 | 2 | 17 | 3 | 2 | 4.21 |
| SP | Vazquez, J.Vazquez, Javier # >> | 33 | 2009 | R | 86 | 25 | 25 | 12 | 6 | 4.50 | .272 | 1.08 | 8.0 | 1.7 | 8.7 | 132.0 | 117 | 66 | 66 | 22 | 25 | 128 | 0 | 0 | 0 | 0 | 9 | 6 | 3 | 3.93 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 67 | 25 | 25 | 8 | 7 | 5.52 | .330 | 1.45 | 9.8 | 3.3 | 6.5 | 124.0 | 135 | 79 | 76 | 19 | 45 | 90 | 1 | 0 | 0 | 0 | 9 | 3 | 3 | 4.70 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 65 | 0 | 6 | 0 | 3.04 | .295 | 1.24 | 8.9 | 2.4 | 8.9 | 91.2 | 90 | 33 | 31 | 15 | 24 | 90 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 3.99 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 76 | 51 | 0 | 2 | 4 | 3.03 | .297 | 1.24 | 8.2 | 3.0 | 9.0 | 65.1 | 59 | 23 | 22 | 5 | 22 | 65 | 0 | 4 | 3 | 0 | 0 | 2 | 1 | 3.11 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 40 | 35 | 0 | 3 | 2 | 3.35 | .279 | 1.16 | 7.3 | 3.1 | 9.0 | 43.0 | 35 | 18 | 16 | 4 | 15 | 43 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.26 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 55 | 0 | 5 | 5 | 5.10 | .336 | 1.50 | 8.3 | 5.3 | 9.6 | 65.1 | 60 | 37 | 37 | 10 | 38 | 69 | 0 | 5 | 4 | 0 | 0 | 1 | 1 | 4.68 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 45 | 28 | 0 | 1 | 0 | 2.02 | .305 | 1.23 | 7.2 | 4.1 | 7.2 | 35.2 | 28 | 9 | 8 | 4 | 16 | 28 | 0 | 5 | 1 | 0 | 0 | 3 | 0 | 4.51 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 54 | 37 | 0 | 4 | 4 | 4.23 | .256 | 1.01 | 6.1 | 3.1 | 5.1 | 44.2 | 30 | 21 | 21 | 9 | 15 | 25 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 5.61 |