| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 93 | 25 | 25 | 11 | 7 | 3.45 | .288 | 1.19 | 8.2 | 2.5 | 5.5 | 174.2 | 159 | 75 | 67 | 14 | 49 | 106 | 1 | 0 | 0 | 0 | 16 | 4 | 7 | 3.74 |
| SP | Lester, J.Lester, Jon # >> | 32 | 2016 | L | 89 | 24 | 24 | 10 | 7 | 4.78 | .312 | 1.35 | 8.9 | 3.2 | 6.2 | 147.0 | 145 | 81 | 78 | 20 | 53 | 102 | 0 | 0 | 0 | 0 | 14 | 2 | 0 | 4.50 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 26 | 2016 | R | 91 | 24 | 24 | 7 | 9 | 4.59 | .299 | 1.26 | 8.3 | 3.0 | 6.4 | 151.0 | 140 | 82 | 77 | 21 | 50 | 107 | 0 | 0 | 0 | 0 | 12 | 3 | 1 | 4.44 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 87 | 23 | 23 | 11 | 9 | 3.58 | .295 | 1.25 | 7.3 | 4.0 | 7.7 | 151.0 | 122 | 61 | 60 | 16 | 67 | 129 | 0 | 0 | 0 | 0 | 15 | 1 | 8 | 4.02 |
| SP | Reulbach, E.Reulbach, Ed >> | 26 | 1908 | R | 72 | 23 | 23 | 9 | 10 | 4.05 | .307 | 1.31 | 7.7 | 4.1 | 4.5 | 146.2 | 125 | 73 | 66 | 21 | 67 | 73 | 1 | 0 | 0 | 1 | 14 | 3 | 3 | 5.31 |
| CL | Chapman, A.Chapman, Aroldis † >> | 28 | 2016 | L | 99 | 47 | 0 | 4 | 2 | 1.38 | .227 | 0.86 | 4.0 | 3.8 | 9.7 | 52.1 | 23 | 8 | 8 | 1 | 22 | 56 | 0 | 27 | 1 | 0 | 0 | 1 | 2 | 2.42 |
| SU | Gordon, T.Gordon, Tom # >> | 34 | 2001 | R | 84 | 51 | 0 | 1 | 4 | 5.40 | .330 | 1.48 | 8.8 | 4.5 | 10.8 | 50.0 | 49 | 31 | 30 | 6 | 25 | 60 | 0 | 3 | 7 | 0 | 0 | 0 | 3 | 3.66 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 73 | 67 | 0 | 1 | 2 | 5.59 | .336 | 1.50 | 10.9 | 2.6 | 10.6 | 58.0 | 70 | 39 | 36 | 11 | 17 | 68 | 0 | 1 | 3 | 0 | 0 | 1 | 3 | 4.05 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 25 | 2001 | R | 62 | 42 | 0 | 2 | 3 | 4.82 | .329 | 1.47 | 7.8 | 5.6 | 9.2 | 37.1 | 32 | 22 | 20 | 6 | 23 | 38 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.92 |
| RP | Dotel, O.Dotel, Octavio >> | 39 | 2012 | R | 59 | 29 | 0 | 1 | 3 | 6.38 | .351 | 1.63 | 9.4 | 5.3 | 7.9 | 24.0 | 25 | 19 | 17 | 3 | 14 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.63 |
| RP | Montgomery, M.Montgomery, Mike >> | 26 | 2016 | L | 50 | 48 | 0 | 2 | 1 | 3.58 | .289 | 1.22 | 6.8 | 4.4 | 7.3 | 37.2 | 28 | 17 | 15 | 6 | 18 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 4.95 |