| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 31 | 31 | 10 | 8 | 5.09 | .327 | 1.44 | 8.8 | 4.2 | 7.7 | 194.1 | 190 | 117 | 110 | 26 | 90 | 166 | 0 | 0 | 0 | 0 | 16 | 3 | 1 | 4.47 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 30 | 30 | 17 | 9 | 3.39 | .288 | 1.20 | 7.7 | 3.1 | 5.2 | 199.0 | 170 | 82 | 75 | 22 | 68 | 116 | 2 | 0 | 0 | 0 | 19 | 4 | 2 | 4.36 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 30 | 30 | 13 | 7 | 4.19 | .333 | 1.47 | 10.5 | 2.8 | 4.8 | 182.2 | 212 | 101 | 85 | 19 | 56 | 97 | 0 | 0 | 0 | 0 | 16 | 5 | 8 | 4.30 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 30 | 30 | 5 | 13 | 6.12 | .359 | 1.65 | 10.4 | 4.4 | 7.7 | 156.0 | 180 | 121 | 106 | 21 | 77 | 133 | 0 | 0 | 0 | 0 | 11 | 5 | 5 | 4.62 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 88 | 69 | 0 | 4 | 2 | 2.03 | .260 | 1.04 | 7.7 | 1.6 | 9.8 | 71.0 | 61 | 20 | 16 | 8 | 13 | 77 | 0 | 49 | 6 | 0 | 0 | 1 | 0 | 2.89 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 72 | 0 | 3 | 2 | 3.55 | .293 | 1.25 | 8.8 | 2.5 | 7.7 | 78.2 | 76 | 37 | 31 | 11 | 22 | 67 | 0 | 5 | 3 | 0 | 0 | 0 | 1 | 3.96 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 87 | 0 | 13 | 5 | 5.08 | .345 | 1.54 | 8.1 | 5.8 | 10.0 | 102.2 | 92 | 65 | 58 | 11 | 66 | 113 | 0 | 1 | 4 | 0 | 0 | 4 | 1 | 4.25 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 71 | 0 | 4 | 4 | 4.32 | .321 | 1.38 | 10.1 | 2.4 | 9.7 | 83.1 | 93 | 52 | 40 | 14 | 22 | 89 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 3.95 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 52 | 0 | 5 | 3 | 3.98 | .315 | 1.34 | 8.3 | 3.8 | 8.8 | 54.1 | 50 | 28 | 24 | 5 | 23 | 53 | 0 | 0 | 2 | 0 | 0 | 2 | 3 | 3.63 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 43 | 0 | 4 | 1 | 6.25 | .366 | 1.69 | 8.6 | 6.8 | 9.2 | 40.1 | 38 | 30 | 28 | 3 | 30 | 41 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.33 |