| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 81 | 31 | 31 | 18 | 8 | 2.74 | .269 | 1.05 | 6.3 | 3.2 | 7.2 | 207.0 | 144 | 70 | 63 | 19 | 74 | 165 | 2 | 0 | 0 | 0 | 22 | 10 | 6 | 3.82 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 60 | 31 | 31 | 18 | 7 | 3.00 | .289 | 1.18 | 6.1 | 4.5 | 3.3 | 210.1 | 142 | 77 | 70 | 11 | 106 | 78 | 1 | 0 | 0 | 0 | 21 | 9 | 4 | 4.58 |
| SP | Lundgren, C.Lundgren, Carl † >> | 27 | 1907 | R | 43 | 30 | 30 | 17 | 8 | 3.06 | .284 | 1.17 | 7.0 | 3.5 | 4.2 | 232.0 | 181 | 84 | 79 | 23 | 91 | 108 | 7 | 0 | 0 | 2 | 20 | 4 | 1 | 4.59 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 29 | 29 | 9 | 9 | 3.17 | .279 | 1.13 | 7.1 | 3.0 | 5.2 | 184.1 | 146 | 71 | 65 | 16 | 62 | 106 | 5 | 0 | 0 | 2 | 18 | 6 | 4 | 4.09 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 102 | 0 | 2 | 3 | 3.65 | .262 | 1.04 | 6.9 | 2.4 | 8.6 | 74.0 | 57 | 32 | 30 | 10 | 20 | 71 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 3.73 |
| RP | Miller, A.Miller, Andrew >> | 32 | 2017 | L | 86 | 92 | 0 | 3 | 0 | 1.09 | .262 | 1.04 | 6.1 | 3.3 | 8.1 | 74.1 | 50 | 9 | 9 | 3 | 27 | 67 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 2.89 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 82 | 0 | 4 | 1 | 1.79 | .249 | 0.98 | 4.6 | 4.3 | 8.7 | 55.1 | 28 | 12 | 11 | 2 | 26 | 53 | 0 | 8 | 1 | 0 | 0 | 1 | 1 | 3.02 |
| RP | Brewer, J.Brewer, Jim † >> | 35 | 1972 | L | 73 | 78 | 0 | 8 | 0 | 1.66 | .213 | 0.81 | 4.7 | 2.7 | 4.8 | 54.1 | 28 | 10 | 10 | 5 | 16 | 29 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 4.02 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 46 | 0 | 3 | 2 | 2.87 | .260 | 1.05 | 6.1 | 3.5 | 10.2 | 31.1 | 21 | 10 | 10 | 4 | 12 | 35 | 0 | 5 | 3 | 0 | 0 | 0 | 1 | 3.58 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 33 | 60 | 0 | 3 | 2 | 3.24 | .306 | 1.29 | 7.1 | 4.6 | 6.3 | 33.1 | 26 | 12 | 12 | 2 | 17 | 23 | 0 | 11 | 2 | 0 | 0 | 1 | 0 | 4.03 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 28 | 0 | 3 | 2 | 2.52 | .279 | 1.16 | 5.4 | 5.0 | 9.0 | 25.0 | 15 | 7 | 7 | 2 | 14 | 25 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 3.72 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 35 | 0 | 0 | 3 | 4.01 | .299 | 1.28 | 6.3 | 5.5 | 5.2 | 33.2 | 23 | 15 | 15 | 4 | 20 | 19 | 0 | 7 | 0 | 0 | 0 | 0 | 1 | 5.24 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 3 | 0 | 0 | 0 | 0.00 | .375 | 1.80 | 6.0 | 12.0 | 12.0 | 3.1 | 2 | 0 | 0 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.33 |