| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 11 | 11 | 4 | 3 | 4.48 | .316 | 1.35 | 8.8 | 3.4 | 10.0 | 74.1 | 72 | 39 | 37 | 12 | 28 | 82 | 0 | 0 | 0 | 0 | 5 | 3 | 0 | 4.15 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 11 | 11 | 1 | 4 | 5.00 | .327 | 1.41 | 9.5 | 3.3 | 7.8 | 66.2 | 70 | 45 | 37 | 16 | 24 | 57 | 0 | 0 | 0 | 0 | 3 | 3 | 0 | 5.65 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 10 | 10 | 2 | 7 | 4.56 | .324 | 1.41 | 9.7 | 3.0 | 3.7 | 75.0 | 81 | 45 | 38 | 4 | 25 | 31 | 1 | 0 | 0 | 0 | 4 | 2 | 4 | 3.95 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 12 | 10 | 0 | 8 | 7.18 | .372 | 1.76 | 12.1 | 3.9 | 3.5 | 67.2 | 90 | 62 | 54 | 11 | 29 | 26 | 1 | 0 | 0 | 0 | 3 | 1 | 1 | 5.70 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 27 | 0 | 5 | 1 | 3.48 | .279 | 1.16 | 8.5 | 2.2 | 9.8 | 33.2 | 31 | 17 | 13 | 5 | 8 | 36 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 3.52 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 17 | 0 | 0 | 1 | 6.98 | .326 | 1.45 | 10.9 | 2.4 | 8.1 | 19.1 | 23 | 15 | 15 | 5 | 5 | 17 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 5.42 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 10 | 0 | 2 | 0 | 1.26 | .283 | 1.12 | 5.8 | 4.5 | 11.6 | 14.1 | 9 | 3 | 2 | 2 | 7 | 18 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 78 | 11 | 0 | 1 | 0 | 7.71 | .500 | 3.00 | 18.0 | 9.0 | 9.0 | 7.0 | 14 | 8 | 6 | 1 | 7 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.86 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 1 | 0 | 0 | 0 | 0.00 | .500 | 3.00 | - | - | - | 0.1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | - |