| SP | Koufax, S.Koufax, Sandy † # >> | 30 | 1965 | L | 97 | 26 | 26 | 12 | 8 | 3.48 | .279 | 1.14 | 7.6 | 2.6 | 8.2 | 209.2 | 177 | 83 | 81 | 21 | 61 | 190 | 8 | 0 | 0 | 4 | 14 | 6 | 5 | 3.45 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 25 | 25 | 8 | 9 | 4.09 | .311 | 1.34 | 9.1 | 3.0 | 7.8 | 156.1 | 157 | 72 | 71 | 20 | 52 | 135 | 0 | 0 | 0 | 0 | 14 | 3 | 3 | 3.99 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 24 | 24 | 9 | 11 | 5.72 | .334 | 1.50 | 10.8 | 2.8 | 4.3 | 163.2 | 195 | 119 | 104 | 25 | 50 | 78 | 3 | 0 | 0 | 0 | 9 | 1 | 2 | 4.98 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 78 | 0 | 2 | 1 | 2.90 | .259 | 1.05 | 7.0 | 2.5 | 7.0 | 62.0 | 48 | 25 | 20 | 4 | 17 | 48 | 0 | 1 | 0 | 0 | 0 | 0 | 5 | 3.11 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 54 | 0 | 2 | 6 | 4.62 | .330 | 1.48 | 9.7 | 3.7 | 5.9 | 64.1 | 69 | 33 | 33 | 5 | 26 | 42 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 3.92 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 47 | 0 | 4 | 2 | 3.78 | .326 | 1.45 | 6.8 | 6.4 | 9.7 | 52.1 | 39 | 22 | 22 | 6 | 37 | 56 | 0 | 5 | 2 | 0 | 0 | 0 | 3 | 4.48 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 57 | 41 | 0 | 2 | 0 | 3.67 | .348 | 1.60 | 7.7 | 6.9 | 7.9 | 34.1 | 29 | 15 | 14 | 3 | 26 | 30 | 0 | 4 | 0 | 0 | 0 | 0 | 4 | 4.68 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 1 | 0 | 1 | 0 | 0.00 | .200 | 0.75 | 0.0 | 9.0 | 9.0 | 1.1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |