| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 17 | 17 | 9 | 5 | 4.18 | .319 | 1.36 | 7.5 | 4.7 | 8.1 | 114.0 | 95 | 53 | 53 | 8 | 60 | 102 | 0 | 0 | 0 | 0 | 10 | 5 | 1 | 3.83 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 16 | 16 | 8 | 6 | 4.25 | .269 | 1.09 | 8.0 | 1.8 | 4.5 | 112.1 | 100 | 54 | 53 | 11 | 22 | 56 | 3 | 0 | 0 | 0 | 8 | 2 | 1 | 3.92 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 16 | 16 | 7 | 2 | 3.54 | .290 | 1.21 | 7.6 | 3.3 | 7.5 | 114.1 | 96 | 50 | 45 | 8 | 42 | 95 | 2 | 0 | 0 | 1 | 10 | 2 | 0 | 3.40 |
| SP | Reulbach, E.Reulbach, Ed # >> | 24 | 1906 | R | 60 | 15 | 15 | 5 | 4 | 4.29 | .342 | 1.51 | 8.6 | 5.0 | 4.4 | 92.1 | 88 | 53 | 44 | 11 | 51 | 45 | 0 | 0 | 0 | 0 | 9 | 5 | 2 | 5.40 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 49 | 0 | 0 | 3 | 3.19 | .257 | 1.04 | 5.5 | 4.0 | 9.0 | 36.2 | 22 | 14 | 13 | 1 | 16 | 36 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 2.69 |
| CL | Saito, T.Saito, Takashi † >> | 37 | 2007 | R | 91 | 34 | 0 | 3 | 4 | 2.97 | .291 | 1.17 | 7.9 | 2.7 | 8.5 | 33.1 | 29 | 11 | 11 | 1 | 10 | 31 | 0 | 11 | 2 | 0 | 0 | 2 | 0 | 2.61 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 29 | 0 | 3 | 0 | 1.06 | .297 | 1.21 | 6.1 | 4.8 | 8.5 | 34.0 | 23 | 6 | 4 | 1 | 18 | 32 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 3.26 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 24 | 0 | 1 | 2 | 6.65 | .343 | 1.57 | 8.2 | 5.9 | 5.9 | 23.0 | 21 | 17 | 17 | 3 | 15 | 15 | 0 | 6 | 2 | 0 | 0 | 0 | 0 | 5.35 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 17 | 0 | 2 | 3 | 2.75 | .352 | 1.63 | 9.5 | 5.7 | 9.9 | 19.2 | 20 | 7 | 6 | 0 | 12 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.68 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 61 | 9 | 0 | 0 | 0 | 6.30 | .286 | 1.10 | 8.1 | 1.8 | 2.7 | 10.0 | 9 | 7 | 7 | 3 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 7.20 |