| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 34 | 34 | 13 | 12 | 4.64 | .320 | 1.40 | 9.4 | 3.2 | 8.9 | 219.1 | 229 | 121 | 113 | 31 | 79 | 216 | 3 | 0 | 0 | 2 | 15 | 1 | 6 | 3.96 |
| SP | Fernandez, S.Fernandez, Sid # >> | 23 | 1985 | L | 49 | 33 | 32 | 11 | 12 | 4.16 | .311 | 1.33 | 7.3 | 4.7 | 7.7 | 210.0 | 170 | 107 | 97 | 24 | 110 | 179 | 1 | 0 | 0 | 0 | 18 | 4 | 7 | 4.41 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 18 | 14 | 6 | 5 | 3.40 | .303 | 1.27 | 7.5 | 4.1 | 4.6 | 100.2 | 83 | 48 | 38 | 9 | 45 | 51 | 1 | 0 | 0 | 1 | 8 | 3 | 0 | 4.59 |
| SP | Carlton, S.Carlton, Steve † >> | 28 | 1972 | L | 51 | 31 | 31 | 16 | 13 | 4.50 | .313 | 1.35 | 8.7 | 3.5 | 5.2 | 220.0 | 212 | 118 | 110 | 23 | 85 | 126 | 10 | 0 | 0 | 3 | 13 | 3 | 4 | 4.41 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 86 | 0 | 7 | 4 | 2.24 | .273 | 1.10 | 5.3 | 4.6 | 10.9 | 128.2 | 76 | 37 | 32 | 5 | 65 | 155 | 0 | 15 | 4 | 0 | 0 | 4 | 0 | 2.70 |
| RP | Nathan, J.Nathan, Joe # >> | 32 | 2006 | R | 86 | 75 | 0 | 3 | 4 | 5.58 | .353 | 1.64 | 9.9 | 5.0 | 9.3 | 80.2 | 88 | 50 | 50 | 10 | 44 | 83 | 0 | 9 | 2 | 0 | 0 | 0 | 6 | 4.20 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 30 | 0 | 1 | 3 | 3.77 | .317 | 1.40 | 9.0 | 3.9 | 7.7 | 28.2 | 28 | 13 | 12 | 4 | 12 | 24 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.43 |