| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 34 | 34 | 12 | 15 | 4.30 | .291 | 1.23 | 8.4 | 2.7 | 8.5 | 234.2 | 218 | 120 | 112 | 29 | 70 | 221 | 6 | 0 | 0 | 1 | 19 | 1 | 3 | 3.63 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 32 | 32 | 13 | 10 | 4.45 | .308 | 1.32 | 9.2 | 2.7 | 8.4 | 192.1 | 196 | 96 | 95 | 34 | 58 | 180 | 0 | 0 | 0 | 0 | 18 | 3 | 5 | 4.38 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 31 | 31 | 7 | 16 | 6.26 | .323 | 1.41 | 9.5 | 3.3 | 4.3 | 175.1 | 184 | 129 | 122 | 20 | 64 | 84 | 2 | 0 | 0 | 0 | 12 | 3 | 3 | 4.67 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 80 | 0 | 4 | 10 | 3.75 | .288 | 1.20 | 8.0 | 2.9 | 8.2 | 86.1 | 76 | 38 | 36 | 9 | 28 | 78 | 0 | 33 | 7 | 0 | 0 | 1 | 2 | 3.56 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 76 | 0 | 6 | 5 | 4.59 | .332 | 1.47 | 8.3 | 4.9 | 9.2 | 82.1 | 76 | 45 | 42 | 16 | 45 | 84 | 0 | 3 | 3 | 0 | 0 | 2 | 0 | 5.21 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 62 | 0 | 2 | 3 | 3.88 | .292 | 1.21 | 7.2 | 3.8 | 10.7 | 69.2 | 55 | 30 | 30 | 9 | 29 | 82 | 0 | 3 | 1 | 0 | 0 | 2 | 3 | 3.67 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 46 | 0 | 2 | 0 | 4.11 | .329 | 1.45 | 9.5 | 3.6 | 9.5 | 50.1 | 53 | 23 | 23 | 9 | 20 | 53 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.48 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 16 | 1 | 1 | 3 | 4.81 | .314 | 1.37 | 9.5 | 3.0 | 8.1 | 39.1 | 41 | 21 | 21 | 5 | 13 | 35 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.87 |