| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 37 | 37 | 13 | 14 | 3.69 | .278 | 1.14 | 8.0 | 2.3 | 5.2 | 280.1 | 250 | 118 | 115 | 32 | 70 | 163 | 13 | 0 | 0 | 2 | 21 | 4 | 0 | 4.11 |
| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 83 | 35 | 35 | 18 | 11 | 3.33 | .264 | 1.05 | 8.1 | 1.3 | 4.6 | 270.0 | 243 | 103 | 100 | 14 | 40 | 138 | 10 | 0 | 0 | 0 | 27 | 8 | 7 | 3.19 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 34 | 34 | 15 | 14 | 3.83 | .307 | 1.32 | 8.2 | 3.6 | 5.5 | 247.0 | 225 | 105 | 105 | 25 | 100 | 152 | 7 | 0 | 0 | 1 | 21 | 4 | 7 | 4.35 |
| SP | Drysdale, D.Drysdale, Don # >> | 28 | 1964 | R | 59 | 34 | 34 | 10 | 14 | 5.43 | .322 | 1.40 | 9.8 | 2.8 | 5.0 | 223.2 | 244 | 138 | 135 | 26 | 69 | 123 | 8 | 0 | 0 | 1 | 12 | 5 | 8 | 4.41 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 31 | 31 | 14 | 15 | 4.20 | .316 | 1.37 | 9.6 | 2.8 | 4.7 | 212.1 | 225 | 105 | 99 | 31 | 65 | 111 | 3 | 0 | 0 | 1 | 17 | 4 | 10 | 4.83 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 87 | 0 | 5 | 6 | 2.45 | .263 | 1.07 | 6.1 | 3.6 | 8.8 | 110.0 | 74 | 30 | 30 | 11 | 44 | 107 | 0 | 12 | 4 | 0 | 0 | 0 | 1 | 3.55 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 59 | 0 | 8 | 4 | 5.04 | .294 | 1.25 | 9.7 | 1.7 | 9.8 | 69.2 | 74 | 40 | 39 | 10 | 13 | 75 | 0 | 8 | 1 | 0 | 0 | 0 | 2 | 3.28 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 41 | 0 | 2 | 4 | 2.62 | .267 | 1.05 | 6.4 | 3.1 | 8.2 | 55.0 | 39 | 19 | 16 | 4 | 19 | 50 | 0 | 7 | 1 | 0 | 0 | 2 | 2 | 3.27 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 26 | 0 | 1 | 2 | 6.38 | .321 | 1.42 | 7.5 | 5.3 | 9.4 | 24.0 | 20 | 17 | 17 | 3 | 14 | 25 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.29 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 25 | 0 | 0 | 0 | 3.33 | .330 | 1.44 | 10.9 | 2.3 | 9.0 | 24.1 | 29 | 9 | 9 | 0 | 6 | 24 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1.88 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Newhouser, H.Newhouser, Hal >> | 25 | 1946 | L | 31 | 7 | 0 | 1 | 0 | 7.16 | .395 | 1.96 | 12.9 | 5.1 | 5.1 | 16.1 | 23 | 13 | 13 | 3 | 9 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |