| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 34 | 34 | 13 | 16 | 3.55 | .288 | 1.20 | 7.8 | 3.0 | 8.1 | 256.1 | 223 | 107 | 101 | 26 | 84 | 229 | 16 | 0 | 0 | 5 | 22 | 4 | 7 | 3.56 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 33 | 33 | 7 | 10 | 5.18 | .337 | 1.51 | 10.6 | 3.1 | 5.4 | 161.2 | 189 | 94 | 93 | 24 | 55 | 96 | 0 | 0 | 0 | 0 | 9 | 3 | 5 | 4.83 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 32 | 32 | 12 | 14 | 4.68 | .306 | 1.29 | 8.7 | 2.9 | 7.1 | 211.2 | 205 | 113 | 110 | 31 | 69 | 166 | 6 | 0 | 0 | 1 | 16 | 6 | 1 | 4.40 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 32 | 32 | 14 | 10 | 4.68 | .317 | 1.38 | 9.6 | 2.8 | 4.5 | 188.1 | 201 | 99 | 98 | 22 | 58 | 95 | 1 | 0 | 0 | 1 | 16 | 3 | 8 | 4.48 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 31 | 31 | 8 | 17 | 4.93 | .303 | 1.28 | 8.9 | 2.7 | 5.0 | 208.0 | 205 | 120 | 114 | 31 | 62 | 115 | 9 | 0 | 0 | 2 | 12 | 4 | 8 | 4.78 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 79 | 0 | 2 | 5 | 3.39 | .270 | 1.10 | 7.2 | 2.8 | 10.1 | 111.2 | 89 | 45 | 42 | 13 | 34 | 125 | 0 | 3 | 3 | 0 | 0 | 1 | 3 | 3.22 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 77 | 0 | 6 | 8 | 3.36 | .287 | 1.18 | 7.5 | 3.2 | 8.4 | 101.2 | 84 | 39 | 38 | 6 | 36 | 94 | 0 | 7 | 1 | 0 | 0 | 3 | 1 | 3.07 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 69 | 0 | 3 | 4 | 4.84 | .330 | 1.45 | 8.6 | 4.6 | 5.3 | 87.1 | 83 | 49 | 47 | 13 | 44 | 51 | 0 | 6 | 5 | 0 | 0 | 2 | 4 | 5.36 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 49 | 0 | 4 | 1 | 5.02 | .301 | 1.26 | 8.4 | 3.0 | 5.7 | 57.1 | 53 | 34 | 32 | 4 | 19 | 36 | 0 | 5 | 0 | 0 | 0 | 2 | 1 | 3.75 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 0 | 0 | 0 | 0.00 | .077 | 0.25 | 2.3 | 0.0 | 2.3 | 4.0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.50 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 33 | 0 | 0 | 6 | 5.06 | .355 | 1.65 | 10.9 | 4.2 | 8.5 | 58.2 | 70 | 34 | 33 | 6 | 27 | 55 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 3.84 |