| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 17 | 17 | 7 | 6 | 3.10 | .285 | 1.16 | 6.9 | 3.6 | 7.5 | 130.2 | 100 | 46 | 45 | 14 | 52 | 108 | 7 | 0 | 0 | 0 | 11 | 4 | 0 | 4.03 |
| SP | Brown, M.Brown, Mordecai † # >> | 32 | 1908 | R | 85 | 17 | 17 | 11 | 2 | 3.28 | .257 | 1.03 | 7.7 | 1.6 | 5.1 | 137.0 | 117 | 50 | 50 | 16 | 24 | 77 | 5 | 0 | 0 | 1 | 11 | 1 | 2 | 3.94 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 16 | 16 | 1 | 9 | 6.11 | .370 | 1.71 | 12.6 | 2.9 | 4.7 | 101.2 | 141 | 76 | 69 | 22 | 33 | 53 | 1 | 0 | 0 | 0 | 4 | 5 | 2 | 5.91 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 16 | 16 | 5 | 6 | 5.20 | .325 | 1.43 | 9.3 | 3.6 | 5.4 | 107.1 | 111 | 69 | 62 | 19 | 43 | 64 | 4 | 0 | 0 | 0 | 6 | 1 | 5 | 5.35 |
| SP | Tudor, J.Tudor, John † >> | 31 | 1985 | L | 63 | 16 | 16 | 9 | 3 | 3.84 | .285 | 1.19 | 8.2 | 2.6 | 4.5 | 119.2 | 108 | 51 | 51 | 12 | 34 | 60 | 6 | 0 | 0 | 1 | 10 | 1 | 1 | 4.18 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 40 | 0 | 4 | 5 | 4.63 | .309 | 1.30 | 8.2 | 3.7 | 9.2 | 44.2 | 40 | 25 | 23 | 8 | 18 | 45 | 0 | 8 | 3 | 0 | 0 | 2 | 2 | 4.68 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 29 | 0 | 3 | 4 | 5.55 | .310 | 1.32 | 10.8 | 1.3 | 6.4 | 35.2 | 42 | 22 | 22 | 6 | 5 | 25 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.31 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 20 | 0 | 3 | 1 | 3.03 | .263 | 1.07 | 7.0 | 2.8 | 3.7 | 32.2 | 25 | 11 | 11 | 4 | 10 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.75 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 54 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 59 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Russell, R.Russell, Reb >> | 27 | 1916 | L | 52 | 10 | 0 | 3 | 0 | 3.21 | .236 | 0.93 | 5.8 | 2.6 | 4.5 | 14.0 | 9 | 5 | 5 | 1 | 4 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.79 |