| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 16 | 16 | 6 | 6 | 3.48 | .282 | 1.14 | 7.8 | 2.5 | 9.1 | 106.0 | 92 | 41 | 41 | 16 | 29 | 107 | 0 | 0 | 0 | 0 | 11 | 4 | 0 | 3.88 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 16 | 16 | 5 | 8 | 4.12 | .294 | 1.22 | 8.8 | 2.2 | 5.6 | 126.2 | 123 | 59 | 58 | 15 | 31 | 79 | 4 | 0 | 0 | 0 | 8 | 4 | 1 | 4.13 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 66 | 15 | 15 | 5 | 6 | 4.38 | .317 | 1.35 | 7.9 | 4.3 | 5.9 | 102.2 | 90 | 55 | 50 | 10 | 49 | 67 | 2 | 0 | 0 | 1 | 9 | 4 | 5 | 4.52 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 39 | 0 | 2 | 2 | 3.61 | .290 | 1.17 | 6.4 | 4.2 | 12.3 | 52.1 | 37 | 21 | 21 | 7 | 24 | 71 | 0 | 1 | 1 | 0 | 0 | 3 | 2 | 3.58 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 14 | 0 | 2 | 1 | 6.08 | .394 | 1.95 | 9.7 | 8.3 | 9.0 | 13.1 | 14 | 9 | 9 | 5 | 12 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 8.77 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 8 | 0 | 0 | 0 | 0.90 | .211 | 0.80 | 3.6 | 3.6 | 9.0 | 10.0 | 4 | 1 | 1 | 0 | 4 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.20 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 0 | 0 | 0 | 10.80 | .444 | 2.40 | 9.0 | 27.0 | 9.0 | 1.2 | 1 | 2 | 2 | 0 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 10.00 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 3 | 0 | 0 | 1 | 3.68 | .241 | 0.95 | 9.0 | 0.0 | 6.4 | 7.1 | 7 | 3 | 3 | 1 | 0 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.43 |