| SP | Gausman, K.Gausman, Kevin † >> | 30 | 2021 | R | 94 | 33 | 33 | 15 | 10 | 3.00 | .292 | 1.19 | 8.0 | 2.8 | 10.4 | 209.2 | 185 | 80 | 70 | 21 | 64 | 241 | 2 | 0 | 0 | 1 | 26 | 11 | 4 | 3.08 |
| SP | Morton, C.Morton, Charlie >> | 38 | 2021 | R | 93 | 33 | 33 | 9 | 11 | 4.18 | .320 | 1.36 | 8.2 | 4.1 | 11.7 | 181.0 | 164 | 92 | 84 | 24 | 82 | 235 | 0 | 0 | 0 | 0 | 14 | 9 | 3 | 3.64 |
| SP | Anderson, I.Anderson, Ian † # >> | 23 | 2021 | R | 69 | 33 | 33 | 17 | 6 | 3.04 | .281 | 1.13 | 7.2 | 3.0 | 9.5 | 189.1 | 151 | 69 | 64 | 18 | 62 | 200 | 0 | 0 | 0 | 0 | 18 | 9 | 6 | 3.25 |
| SU | Jackson, L.Jackson, Luke >> | 29 | 2021 | R | 77 | 86 | 0 | 8 | 2 | 3.53 | .278 | 1.13 | 5.8 | 4.4 | 10.0 | 104.2 | 67 | 41 | 41 | 12 | 51 | 116 | 0 | 4 | 5 | 0 | 0 | 3 | 6 | 3.83 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 100 | 71 | 0 | 3 | 5 | 4.00 | .277 | 1.12 | 6.5 | 3.6 | 12.3 | 99.0 | 71 | 45 | 44 | 12 | 40 | 135 | 0 | 16 | 10 | 0 | 0 | 3 | 6 | 3.15 |
| RP | Matzek, T.Matzek, Tyler >> | 30 | 2021 | R | 79 | 94 | 0 | 10 | 3 | 3.86 | .351 | 1.57 | 8.0 | 6.2 | 11.3 | 100.1 | 89 | 43 | 43 | 14 | 69 | 126 | 0 | 3 | 3 | 0 | 0 | 5 | 9 | 4.52 |
| RP | Minter, A.Minter, A.J. >> | 27 | 2021 | L | 60 | 93 | 0 | 4 | 4 | 4.25 | .280 | 1.13 | 7.7 | 2.6 | 11.5 | 84.2 | 72 | 40 | 40 | 13 | 24 | 107 | 0 | 7 | 3 | 0 | 0 | 3 | 0 | 3.43 |
| RP | Wisler, M.Wisler, Matt >> | 28 | 2021 | R | 74 | 91 | 0 | 9 | 4 | 3.79 | .283 | 1.14 | 7.7 | 2.6 | 11.4 | 97.1 | 83 | 43 | 41 | 15 | 28 | 123 | 0 | 5 | 3 | 0 | 0 | 4 | 2 | 3.46 |
| RP | Chacin, J.Chacin, Jhoulys >> | 33 | 2021 | R | 53 | 74 | 0 | 3 | 2 | 5.15 | .294 | 1.21 | 7.9 | 3.1 | 8.2 | 85.2 | 75 | 51 | 49 | 11 | 29 | 77 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 4.00 |