| SP | Bauer, T.Bauer, Trevor >> | 30 | 2021 | R | 98 | 33 | 33 | 12 | 11 | 3.79 | .288 | 1.18 | 6.9 | 3.8 | 11.1 | 218.2 | 167 | 95 | 92 | 30 | 91 | 268 | 2 | 0 | 0 | 2 | 21 | 7 | 7 | 3.68 |
| SP | DeSclafani, A.DeSclafani, Anthony >> | 31 | 2021 | R | 78 | 33 | 33 | 12 | 11 | 5.20 | .331 | 1.44 | 9.5 | 3.5 | 7.6 | 183.1 | 193 | 109 | 106 | 37 | 71 | 155 | 1 | 0 | 0 | 1 | 12 | 8 | 11 | 5.23 |
| SP | Castillo, L.Castillo, Luis >> | 28 | 2021 | R | 41 | 32 | 32 | 6 | 9 | 5.15 | .354 | 1.62 | 10.4 | 4.2 | 9.8 | 173.0 | 200 | 100 | 99 | 27 | 80 | 189 | 0 | 0 | 0 | 0 | 11 | 5 | 2 | 4.32 |
| RP | Antone, T.Antone, Tejay >> | 27 | 2021 | R | 98 | 89 | 0 | 6 | 4 | 3.44 | .306 | 1.28 | 7.4 | 4.1 | 10.4 | 133.1 | 110 | 59 | 51 | 15 | 60 | 153 | 0 | 0 | 4 | 0 | 0 | 6 | 4 | 3.65 |
| RP | Iglesias, R.Iglesias, Raisel >> | 31 | 2021 | R | 92 | 79 | 0 | 5 | 7 | 2.83 | .230 | 0.89 | 6.3 | 1.8 | 11.7 | 108.0 | 75 | 41 | 34 | 14 | 21 | 140 | 0 | 0 | 3 | 0 | 0 | 1 | 3 | 2.70 |
| RP | Hembree, H.Hembree, Heath >> | 32 | 2021 | R | 70 | 76 | 0 | 5 | 5 | 5.42 | .317 | 1.37 | 9.0 | 3.4 | 9.9 | 79.2 | 79 | 54 | 48 | 14 | 30 | 87 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 4.32 |
| RP | Santillan, T.Santillan, Tony >> | 24 | 2021 | R | 62 | 51 | 0 | 6 | 4 | 5.71 | .347 | 1.51 | 8.5 | 5.1 | 11.3 | 58.1 | 55 | 38 | 37 | 12 | 33 | 73 | 0 | 0 | 1 | 0 | 0 | 5 | 3 | 5.14 |
| CL | Chapman, A.Chapman, Aroldis † >> | 33 | 2021 | L | 70 | 50 | 0 | 2 | 6 | 4.28 | .329 | 1.43 | 6.9 | 6.0 | 14.8 | 48.1 | 37 | 23 | 23 | 6 | 32 | 79 | 0 | 32 | 7 | 0 | 0 | 2 | 5 | 3.46 |
| RP | Goudeau, A.Goudeau, Ashton >> | 28 | 2021 | R | 65 | 55 | 0 | 6 | 5 | 5.59 | .342 | 1.50 | 9.0 | 4.6 | 7.3 | 106.1 | 106 | 71 | 66 | 17 | 54 | 86 | 0 | 0 | 1 | 0 | 0 | 6 | 5 | 5.16 |