| SP | Bumgarner, M.Bumgarner, Madison >> | 31 | 2021 | L | 61 | 33 | 33 | 14 | 11 | 4.74 | .327 | 1.42 | 9.5 | 3.3 | 7.3 | 191.2 | 202 | 104 | 101 | 25 | 71 | 155 | 0 | 0 | 0 | 0 | 14 | 7 | 1 | 4.30 |
| SP | Anderson, T.Anderson, Tyler >> | 31 | 2021 | L | 44 | 32 | 32 | 9 | 12 | 5.07 | .349 | 1.56 | 10.9 | 3.2 | 8.0 | 174.0 | 211 | 107 | 98 | 18 | 61 | 154 | 1 | 0 | 0 | 1 | 9 | 8 | 4 | 3.76 |
| SP | Sanchez, A.Sanchez, Aaron >> | 28 | 2021 | R | 40 | 32 | 32 | 4 | 4 | 4.31 | .332 | 1.47 | 9.4 | 3.8 | 7.1 | 131.2 | 137 | 64 | 63 | 12 | 56 | 103 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 3.97 |
| RP | Doval, C.Doval, Camilo >> | 23 | 2021 | R | 90 | 86 | 0 | 15 | 7 | 4.41 | .316 | 1.31 | 7.8 | 4.0 | 10.6 | 116.1 | 100 | 58 | 57 | 22 | 52 | 137 | 0 | 1 | 4 | 0 | 0 | 9 | 7 | 4.68 |
| CL | Garcia, J.Garcia, Jarlin >> | 28 | 2021 | L | 86 | 67 | 0 | 5 | 8 | 4.78 | .351 | 1.56 | 10.6 | 3.7 | 9.5 | 69.2 | 81 | 46 | 37 | 16 | 28 | 73 | 0 | 28 | 9 | 0 | 0 | 4 | 3 | 5.29 |
| RP | Pomeranz, D.Pomeranz, Drew >> | 32 | 2021 | L | 75 | 84 | 0 | 5 | 4 | 3.00 | .268 | 1.07 | 5.8 | 3.9 | 10.5 | 114.0 | 73 | 40 | 38 | 9 | 49 | 133 | 0 | 2 | 3 | 0 | 0 | 3 | 7 | 3.06 |
| RP | Littell, Z.Littell, Zack >> | 25 | 2021 | R | 73 | 72 | 0 | 7 | 4 | 4.34 | .289 | 1.17 | 7.4 | 3.1 | 10.1 | 87.0 | 72 | 43 | 42 | 11 | 30 | 98 | 0 | 2 | 4 | 0 | 0 | 4 | 3 | 3.56 |
| RP | Strickland, H.Strickland, Hunter >> | 32 | 2021 | R | 68 | 62 | 0 | 4 | 2 | 3.82 | .327 | 1.42 | 8.2 | 4.6 | 10.6 | 66.0 | 60 | 29 | 28 | 6 | 34 | 78 | 0 | 4 | 2 | 0 | 0 | 2 | 3 | 3.45 |
| RP | Rogers, T.Rogers, Tyler >> | 30 | 2021 | R | 59 | 61 | 0 | 0 | 0 | 3.19 | .293 | 1.23 | 8.9 | 2.3 | 6.3 | 67.2 | 66 | 30 | 24 | 10 | 17 | 47 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.34 |