| SP | Koufax, S.Koufax, Sandy >> | 31 | 1965 | L | 98 | 38 | 38 | 20 | 11 | 3.63 | .284 | 1.17 | 7.7 | 2.9 | 9.7 | 265.0 | 226 | 110 | 107 | 36 | 84 | 286 | 10 | 0 | 0 | 4 | 21 | 5 | 6 | 3.62 |
| SP | Scherzer, M.Scherzer, Max >> | 38 | 2021 | R | 89 | 36 | 36 | 19 | 11 | 4.40 | .303 | 1.28 | 8.3 | 3.2 | 9.8 | 194.1 | 178 | 97 | 95 | 27 | 70 | 212 | 0 | 0 | 0 | 0 | 18 | 5 | 6 | 3.78 |
| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2015 | L | 96 | 35 | 35 | 18 | 7 | 2.95 | .254 | 1.02 | 6.7 | 2.5 | 9.4 | 253.0 | 188 | 86 | 83 | 17 | 69 | 263 | 4 | 0 | 0 | 1 | 26 | 2 | 5 | 2.64 |
| SP | Bauer, T.Bauer, Trevor >> | 31 | 2021 | R | 86 | 35 | 35 | 13 | 14 | 3.84 | .301 | 1.28 | 7.4 | 4.1 | 8.9 | 211.0 | 174 | 96 | 90 | 21 | 97 | 208 | 1 | 0 | 0 | 0 | 22 | 2 | 2 | 3.73 |
| SP | Buehler, W.Buehler, Walker >> | 27 | 2021 | R | 86 | 33 | 33 | 13 | 11 | 3.81 | .298 | 1.26 | 8.0 | 3.3 | 8.3 | 205.1 | 183 | 90 | 87 | 19 | 76 | 189 | 1 | 0 | 0 | 0 | 23 | 2 | 5 | 3.50 |
| RP | Treinen, B.Treinen, Blake >> | 34 | 2021 | R | 75 | 52 | 0 | 5 | 0 | 2.91 | .284 | 1.19 | 7.4 | 3.3 | 10.0 | 46.1 | 38 | 17 | 15 | 7 | 17 | 51 | 0 | 3 | 1 | 0 | 0 | 0 | 3 | 3.87 |
| RP | Knebel, C.Knebel, Corey >> | 30 | 2021 | R | 94 | 24 | 0 | 0 | 2 | 4.26 | .280 | 1.14 | 7.0 | 3.5 | 6.7 | 31.2 | 24 | 16 | 15 | 4 | 12 | 23 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.45 |
| RP | Jansen, K.Jansen, Kenley >> | 34 | 2021 | R | 82 | 23 | 0 | 2 | 0 | 1.90 | .317 | 1.39 | 7.4 | 5.5 | 9.8 | 23.2 | 19 | 5 | 5 | 3 | 14 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.35 |
| RP | Bickford, P.Bickford, Phil >> | 26 | 2021 | R | 89 | 33 | 0 | 1 | 1 | 4.50 | .329 | 1.47 | 8.0 | 5.3 | 9.3 | 36.0 | 32 | 21 | 18 | 8 | 21 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.58 |
| SP | Urias, J.Urias, Julio # >> | 25 | 2021 | L | 81 | 15 | 0 | 1 | 2 | 5.48 | .321 | 1.37 | 9.5 | 3.0 | 9.1 | 70.2 | 74 | 43 | 43 | 13 | 23 | 71 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 4.50 |