| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 20 | 20 | 7 | 9 | 4.05 | .279 | 1.15 | 7.5 | 2.8 | 8.7 | 129.0 | 108 | 61 | 58 | 12 | 40 | 124 | 3 | 0 | 0 | 0 | 12 | 2 | 1 | 3.26 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 20 | 20 | 10 | 4 | 4.97 | .332 | 1.48 | 9.3 | 4.0 | 9.1 | 121.1 | 125 | 70 | 67 | 20 | 54 | 123 | 0 | 0 | 0 | 0 | 10 | 2 | 5 | 4.50 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 77 | 19 | 19 | 3 | 12 | 7.73 | .377 | 1.81 | 12.4 | 3.9 | 5.1 | 89.2 | 123 | 86 | 77 | 20 | 39 | 50 | 0 | 0 | 0 | 0 | 4 | 1 | 2 | 6.15 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 90 | 20 | 19 | 9 | 4 | 3.10 | .279 | 1.16 | 8.2 | 2.3 | 7.1 | 136.1 | 124 | 53 | 47 | 14 | 34 | 108 | 1 | 0 | 0 | 1 | 13 | 0 | 2 | 3.50 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 93 | 35 | 0 | 1 | 3 | 4.81 | .294 | 1.22 | 6.8 | 4.4 | 10.9 | 33.2 | 25 | 18 | 18 | 4 | 16 | 40 | 0 | 20 | 2 | 0 | 0 | 1 | 1 | 3.70 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 89 | 32 | 0 | 1 | 2 | 5.70 | .371 | 1.77 | 11.7 | 4.2 | 6.9 | 30.0 | 39 | 20 | 19 | 6 | 14 | 23 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 5.47 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 36 | 0 | 3 | 1 | 5.48 | .289 | 1.22 | 9.2 | 1.9 | 9.6 | 42.2 | 43 | 27 | 26 | 6 | 9 | 45 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.36 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 19 | 0 | 2 | 1 | 2.75 | .272 | 1.12 | 7.1 | 3.3 | 14.2 | 19.2 | 15 | 6 | 6 | 4 | 7 | 30 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.68 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 14 | 0 | 1 | 2 | 13.06 | .456 | 2.42 | 18.0 | 4.5 | 10.8 | 10.1 | 20 | 15 | 15 | 4 | 5 | 12 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 7.60 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 65 | 24 | 0 | 1 | 0 | 5.19 | .278 | 1.08 | 5.5 | 4.2 | 8.7 | 26.0 | 16 | 15 | 15 | 2 | 12 | 25 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3.69 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 72 | 14 | 0 | 1 | 0 | 5.32 | .341 | 1.52 | 9.4 | 4.4 | 7.4 | 67.2 | 70 | 42 | 40 | 11 | 33 | 55 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 5.06 |