| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 93 | 20 | 20 | 7 | 6 | 4.04 | .292 | 1.20 | 8.1 | 2.8 | 7.1 | 124.2 | 112 | 56 | 56 | 15 | 38 | 98 | 2 | 0 | 0 | 1 | 11 | 4 | 1 | 4.01 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 90 | 19 | 19 | 6 | 8 | 3.89 | .290 | 1.23 | 8.0 | 3.1 | 9.1 | 115.2 | 102 | 52 | 50 | 16 | 40 | 116 | 1 | 0 | 0 | 0 | 12 | 0 | 0 | 3.83 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 70 | 18 | 18 | 3 | 8 | 6.99 | .353 | 1.62 | 10.3 | 4.4 | 6.3 | 92.2 | 105 | 76 | 72 | 15 | 45 | 64 | 2 | 0 | 0 | 0 | 7 | 2 | 2 | 5.26 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 42 | 0 | 3 | 5 | 3.52 | .313 | 1.33 | 6.8 | 5.1 | 12.5 | 46.0 | 35 | 18 | 18 | 5 | 26 | 64 | 0 | 21 | 5 | 0 | 0 | 2 | 3 | 3.46 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 45 | 0 | 2 | 0 | 3.08 | .284 | 1.19 | 8.0 | 2.8 | 8.4 | 61.1 | 54 | 23 | 21 | 7 | 19 | 57 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 3.56 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 55 | 0 | 3 | 3 | 4.91 | .331 | 1.47 | 9.9 | 3.4 | 9.2 | 58.2 | 64 | 34 | 32 | 9 | 22 | 59 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 4.17 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 39 | 0 | 1 | 3 | 3.55 | .286 | 1.20 | 6.0 | 5.0 | 7.6 | 45.2 | 30 | 18 | 18 | 2 | 25 | 38 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 3.56 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 71 | 30 | 0 | 1 | 2 | 5.01 | .303 | 1.31 | 8.8 | 3.1 | 8.1 | 41.1 | 40 | 23 | 23 | 5 | 14 | 37 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 3.80 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 27 | 0 | 2 | 1 | 4.31 | .314 | 1.31 | 6.7 | 5.2 | 10.2 | 31.1 | 23 | 15 | 15 | 7 | 18 | 35 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.61 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 7 | 1 | 4 | 1 | 3.38 | .333 | 1.41 | 7.7 | 5.1 | 6.9 | 21.1 | 18 | 9 | 8 | 0 | 12 | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.48 |