| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 26 | 26 | 7 | 8 | 4.77 | .300 | 1.27 | 8.5 | 3.0 | 8.8 | 173.2 | 163 | 94 | 92 | 24 | 57 | 169 | 2 | 0 | 0 | 1 | 14 | 3 | 3 | 3.89 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 25 | 25 | 11 | 9 | 4.54 | .308 | 1.32 | 9.5 | 2.4 | 4.9 | 176.1 | 186 | 96 | 89 | 24 | 47 | 95 | 4 | 0 | 0 | 1 | 13 | 3 | 3 | 4.55 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 25 | 25 | 7 | 10 | 4.92 | .347 | 1.55 | 9.4 | 4.6 | 5.7 | 170.0 | 177 | 109 | 93 | 18 | 87 | 108 | 3 | 0 | 0 | 0 | 12 | 7 | 5 | 4.76 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 25 | 25 | 6 | 12 | 4.79 | .315 | 1.37 | 8.3 | 4.1 | 6.9 | 133.1 | 122 | 75 | 71 | 18 | 60 | 102 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 4.62 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 65 | 0 | 5 | 1 | 3.19 | .270 | 1.10 | 6.1 | 3.8 | 8.3 | 90.1 | 61 | 33 | 32 | 5 | 38 | 83 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 3.18 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 49 | 0 | 4 | 5 | 2.10 | .269 | 1.10 | 7.3 | 2.7 | 8.2 | 64.1 | 52 | 20 | 15 | 2 | 19 | 58 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 2.48 |
| RP | Dotel, O.Dotel, Octavio † >> | 29 | 2002 | R | 68 | 41 | 0 | 7 | 3 | 4.74 | .321 | 1.42 | 8.8 | 4.2 | 9.0 | 43.2 | 42 | 24 | 23 | 8 | 20 | 43 | 0 | 6 | 3 | 0 | 0 | 0 | 0 | 4.81 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 28 | 0 | 0 | 0 | 3.78 | .285 | 1.20 | 6.3 | 4.6 | 8.0 | 47.2 | 33 | 21 | 20 | 9 | 24 | 42 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.23 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 4 | 0 | 1 | 1 | 1.69 | .238 | 0.94 | 3.6 | 5.4 | 9.0 | 5.1 | 2 | 3 | 1 | 0 | 3 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.80 |