| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 34 | 34 | 12 | 13 | 4.44 | .305 | 1.30 | 9.2 | 2.5 | 8.2 | 241.1 | 246 | 128 | 119 | 30 | 68 | 219 | 6 | 0 | 0 | 0 | 15 | 3 | 5 | 3.68 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 33 | 33 | 9 | 19 | 5.65 | .339 | 1.52 | 9.7 | 4.0 | 7.3 | 207.0 | 224 | 130 | 130 | 25 | 91 | 169 | 5 | 0 | 0 | 1 | 12 | 3 | 4 | 4.30 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 32 | 32 | 13 | 11 | 5.50 | .340 | 1.53 | 9.6 | 4.2 | 5.0 | 199.2 | 213 | 130 | 122 | 42 | 93 | 110 | 1 | 0 | 0 | 0 | 15 | 3 | 4 | 6.09 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 32 | 32 | 10 | 15 | 5.38 | .329 | 1.43 | 9.9 | 3.1 | 4.8 | 197.1 | 216 | 120 | 118 | 36 | 67 | 104 | 2 | 0 | 0 | 0 | 12 | 7 | 5 | 5.45 |
| RP | Rivera, M.Rivera, Mariano $$ >> | 39 | 2008 | R | 85 | 79 | 0 | 5 | 5 | 2.97 | .257 | 1.03 | 7.8 | 1.4 | 9.1 | 100.0 | 87 | 34 | 33 | 8 | 16 | 101 | 0 | 4 | 6 | 0 | 0 | 1 | 1 | 2.53 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 62 | 0 | 2 | 3 | 4.93 | .309 | 1.32 | 7.6 | 4.4 | 10.3 | 76.2 | 64 | 44 | 42 | 13 | 37 | 87 | 0 | 0 | 2 | 0 | 0 | 2 | 3 | 4.47 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 51 | 0 | 1 | 1 | 3.68 | .318 | 1.40 | 7.1 | 5.6 | 8.4 | 58.2 | 46 | 25 | 24 | 7 | 36 | 54 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.57 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 60 | 0 | 6 | 5 | 3.18 | .238 | 0.94 | 6.5 | 1.9 | 8.9 | 65.0 | 47 | 23 | 23 | 8 | 14 | 64 | 0 | 34 | 2 | 0 | 0 | 0 | 2 | 3.28 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 59 | 0 | 1 | 0 | 2.55 | .237 | 0.93 | 5.4 | 3.0 | 8.7 | 60.0 | 36 | 17 | 17 | 7 | 20 | 58 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.58 |