| SP | Lackey, J.Lackey, John # >> | 38 | 2016 | R | 94 | 34 | 34 | 10 | 16 | 5.02 | .347 | 1.55 | 10.3 | 3.7 | 8.9 | 206.0 | 235 | 120 | 115 | 19 | 84 | 204 | 0 | 0 | 0 | 0 | 16 | 10 | 7 | 3.59 |
| SP | Pomeranz, D.Pomeranz, Drew >> | 27 | 2016 | L | 86 | 33 | 33 | 10 | 14 | 4.18 | .321 | 1.37 | 7.5 | 5.0 | 10.3 | 180.2 | 149 | 89 | 84 | 13 | 99 | 205 | 0 | 0 | 0 | 0 | 11 | 8 | 7 | 3.44 |
| SP | McCarthy, B.McCarthy, Brandon >> | 33 | 2016 | R | 63 | 32 | 32 | 7 | 5 | 2.97 | .334 | 1.49 | 7.9 | 5.5 | 8.5 | 133.1 | 117 | 51 | 44 | 6 | 81 | 126 | 0 | 0 | 0 | 0 | 2 | 3 | 4 | 3.59 |
| SP | Sabathia, C.Sabathia, CC >> | 36 | 2016 | L | 51 | 30 | 30 | 8 | 18 | 4.98 | .341 | 1.52 | 10.3 | 3.4 | 6.8 | 177.0 | 203 | 104 | 98 | 20 | 66 | 134 | 0 | 0 | 0 | 0 | 12 | 6 | 3 | 4.18 |
| RP | Torres, C.Torres, Carlos >> | 33 | 2016 | R | 59 | 89 | 0 | 6 | 5 | 2.94 | .294 | 1.25 | 7.9 | 3.3 | 7.8 | 119.1 | 105 | 40 | 39 | 13 | 44 | 103 | 0 | 5 | 3 | 0 | 0 | 0 | 1 | 3.80 |
| RP | Broxton, J.Broxton, Jonathan >> | 32 | 2016 | R | 43 | 84 | 0 | 2 | 6 | 3.12 | .313 | 1.28 | 8.1 | 3.4 | 7.2 | 101.0 | 91 | 36 | 35 | 5 | 38 | 81 | 0 | 12 | 5 | 0 | 0 | 9 | 1 | 3.44 |
| RP | Farquhar, D.Farquhar, Danny >> | 29 | 2016 | R | 32 | 77 | 0 | 0 | 6 | 5.68 | .360 | 1.60 | 9.3 | 5.0 | 9.2 | 84.0 | 87 | 53 | 53 | 12 | 47 | 86 | 0 | 8 | 2 | 0 | 0 | 8 | 3 | 4.77 |
| SP | Liriano, F.Liriano, Francisco >> | 33 | 2016 | L | 39 | 3 | 0 | 0 | 0 | 0.00 | .125 | 0.43 | 0.0 | 4.5 | 4.5 | 2.1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| SP | Greinke, Z.Greinke, Zack >> | 33 | 2016 | R | 49 | 14 | 1 | 1 | 2 | 11.81 | .444 | 2.40 | 14.5 | 7.6 | 8.0 | 26.2 | 42 | 35 | 35 | 9 | 22 | 23 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 8.27 |
| SP | Koehler, T.Koehler, Tom >> | 30 | 2016 | R | 31 | 59 | 0 | 5 | 14 | 6.44 | .393 | 1.89 | 11.5 | 5.6 | 6.9 | 117.1 | 149 | 84 | 84 | 18 | 73 | 90 | 0 | 5 | 4 | 0 | 0 | 6 | 1 | 5.49 |