| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 97 | 30 | 30 | 11 | 8 | 3.86 | .278 | 1.11 | 7.7 | 2.3 | 7.1 | 193.1 | 165 | 84 | 83 | 22 | 50 | 152 | 0 | 0 | 0 | 0 | 16 | 8 | 3 | 3.81 |
| SP | Pomeranz, D.Pomeranz, Drew >> | 27 | 2016 | L | 86 | 29 | 29 | 11 | 9 | 4.40 | .325 | 1.40 | 8.7 | 4.0 | 10.1 | 157.1 | 151 | 84 | 77 | 20 | 70 | 177 | 0 | 0 | 0 | 0 | 10 | 6 | 8 | 3.85 |
| SP | Quintana, J.Quintana, Jose >> | 27 | 2016 | L | 77 | 29 | 29 | 11 | 10 | 4.73 | .315 | 1.35 | 8.9 | 3.3 | 7.2 | 186.2 | 183 | 102 | 98 | 19 | 69 | 149 | 3 | 0 | 0 | 1 | 13 | 5 | 7 | 3.92 |
| SP | Manaea, S.Manaea, Sean † # >> | 24 | 2016 | L | 69 | 30 | 29 | 18 | 8 | 3.66 | .290 | 1.16 | 8.1 | 2.3 | 8.3 | 177.0 | 160 | 74 | 72 | 17 | 45 | 163 | 0 | 0 | 0 | 0 | 15 | 12 | 3 | 3.37 |
| SP | Hamels, C.Hamels, Cole >> | 33 | 2016 | L | 60 | 30 | 29 | 15 | 7 | 4.61 | .331 | 1.43 | 9.4 | 3.5 | 9.4 | 175.2 | 183 | 93 | 90 | 19 | 69 | 182 | 0 | 0 | 0 | 0 | 17 | 9 | 3 | 3.67 |
| CL | Oh, S.Oh, Seung-hwan † >> | 33 | 2016 | R | 94 | 75 | 0 | 3 | 2 | 2.02 | .215 | 0.80 | 5.9 | 1.4 | 9.7 | 80.1 | 52 | 19 | 18 | 4 | 12 | 86 | 0 | 40 | 3 | 0 | 0 | 2 | 0 | 2.03 |
| RP | Strickland, H.Strickland, Hunter >> | 27 | 2016 | R | 58 | 78 | 0 | 2 | 2 | 3.12 | .257 | 1.03 | 6.7 | 2.6 | 6.5 | 86.2 | 64 | 31 | 30 | 7 | 25 | 62 | 0 | 6 | 3 | 0 | 0 | 1 | 1 | 3.52 |