| SP | Bumgarner, M.Bumgarner, Madison >> | 26 | 2016 | L | 97 | 16 | 16 | 6 | 5 | 3.17 | .289 | 1.13 | 8.1 | 2.0 | 9.3 | 116.1 | 105 | 42 | 41 | 13 | 26 | 120 | 3 | 0 | 0 | 2 | 11 | 11 | 1 | 3.34 |
| SP | Darvish, Y.Darvish, Yu # >> | 29 | 2016 | R | 91 | 16 | 16 | 6 | 5 | 5.14 | .318 | 1.37 | 8.9 | 3.5 | 9.8 | 96.1 | 95 | 56 | 55 | 12 | 37 | 104 | 0 | 0 | 0 | 0 | 8 | 3 | 3 | 3.71 |
| SP | Syndergaard, N.Syndergaard, Noah >> | 23 | 2016 | R | 83 | 15 | 15 | 8 | 4 | 4.55 | .295 | 1.24 | 9.1 | 2.0 | 9.7 | 93.0 | 94 | 48 | 47 | 8 | 21 | 100 | 1 | 0 | 0 | 0 | 10 | 2 | 1 | 2.71 |
| SP | De La Rosa, R.De La Rosa, Rubby # >> | 27 | 2016 | R | 73 | 15 | 15 | 1 | 8 | 8.04 | .387 | 1.86 | 11.4 | 5.3 | 9.0 | 56.0 | 71 | 50 | 50 | 12 | 33 | 56 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 5.66 |
| SP | Santana, E.Santana, Ervin # >> | 33 | 2016 | R | 65 | 15 | 15 | 3 | 7 | 5.59 | .333 | 1.48 | 10.5 | 2.9 | 6.7 | 93.1 | 108 | 58 | 58 | 8 | 30 | 69 | 0 | 0 | 0 | 0 | 5 | 2 | 6 | 3.67 |
| CL | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 99 | 38 | 0 | 4 | 2 | 4.50 | .333 | 1.50 | 7.8 | 5.8 | 12.0 | 36.0 | 31 | 18 | 18 | 1 | 23 | 48 | 0 | 15 | 2 | 0 | 0 | 0 | 3 | 2.61 |
| SU | Buchter, R.Buchter, Ryan >> | 29 | 2016 | L | 91 | 37 | 0 | 3 | 1 | 4.28 | .322 | 1.43 | 7.0 | 5.9 | 9.7 | 40.0 | 31 | 19 | 19 | 8 | 26 | 43 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 5.40 |
| RP | Uehara, K.Uehara, Koji >> | 41 | 2016 | R | 89 | 47 | 0 | 1 | 2 | 4.86 | .312 | 1.34 | 9.6 | 2.5 | 9.2 | 46.1 | 49 | 26 | 25 | 12 | 13 | 47 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 5.26 |
| RP | Blanton, J.Blanton, Joe >> | 36 | 2016 | R | 80 | 35 | 0 | 1 | 0 | 2.04 | .242 | 0.93 | 6.5 | 2.1 | 10.2 | 39.2 | 28 | 12 | 9 | 5 | 9 | 44 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 3.18 |
| RP | Diekman, J.Diekman, Jake >> | 29 | 2016 | L | 69 | 45 | 0 | 4 | 1 | 5.64 | .337 | 1.48 | 9.8 | 3.7 | 9.8 | 44.2 | 48 | 28 | 28 | 6 | 18 | 48 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3.95 |