| SP | Scherzer, M.Scherzer, Max >> | 32 | 2016 | R | 100 | 36 | 36 | 17 | 12 | 2.61 | .267 | 1.05 | 6.6 | 2.9 | 9.7 | 258.2 | 190 | 84 | 75 | 31 | 82 | 277 | 1 | 0 | 0 | 1 | 28 | 11 | 0 | 3.50 |
| SP | Darvish, Y.Darvish, Yu # >> | 29 | 2016 | R | 91 | 34 | 34 | 15 | 12 | 4.04 | .307 | 1.29 | 8.5 | 3.1 | 10.5 | 207.1 | 195 | 93 | 93 | 17 | 72 | 241 | 0 | 0 | 0 | 0 | 19 | 9 | 12 | 2.91 |
| SP | Duffy, D.Duffy, Danny # >> | 27 | 2016 | L | 83 | 33 | 33 | 7 | 10 | 4.48 | .305 | 1.28 | 9.2 | 2.3 | 8.5 | 154.2 | 158 | 82 | 77 | 24 | 40 | 146 | 0 | 0 | 0 | 0 | 2 | 6 | 5 | 4.03 |
| SP | Samardzija, J.Samardzija, Jeff >> | 31 | 2016 | R | 68 | 33 | 33 | 9 | 16 | 4.89 | .332 | 1.45 | 9.7 | 3.4 | 7.0 | 220.2 | 237 | 124 | 120 | 28 | 82 | 171 | 1 | 0 | 0 | 0 | 16 | 10 | 2 | 4.35 |
| SP | DeSclafani, A.DeSclafani, Anthony >> | 26 | 2016 | R | 63 | 32 | 31 | 12 | 14 | 4.26 | .312 | 1.30 | 8.6 | 3.1 | 7.4 | 203.0 | 193 | 102 | 96 | 29 | 70 | 166 | 0 | 0 | 1 | 0 | 18 | 13 | 7 | 4.45 |
| CL | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 99 | 67 | 0 | 6 | 2 | 2.47 | .265 | 1.02 | 6.2 | 3.0 | 12.9 | 65.2 | 45 | 19 | 18 | 5 | 22 | 93 | 0 | 40 | 4 | 0 | 0 | 4 | 7 | 2.34 |
| SU | Kimbrel, C.Kimbrel, Craig >> | 28 | 2016 | R | 88 | 68 | 0 | 5 | 1 | 2.42 | .301 | 1.29 | 6.1 | 5.6 | 9.9 | 74.1 | 50 | 21 | 20 | 7 | 46 | 81 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.91 |
| RP | Cishek, S.Cishek, Steve >> | 30 | 2016 | R | 85 | 90 | 0 | 3 | 5 | 3.88 | .301 | 1.25 | 6.9 | 4.4 | 10.4 | 109.0 | 83 | 51 | 47 | 15 | 53 | 126 | 0 | 2 | 3 | 0 | 0 | 5 | 7 | 4.07 |
| RP | Colome, A.Colome, Alex # >> | 27 | 2016 | R | 77 | 82 | 0 | 1 | 7 | 4.48 | .318 | 1.36 | 9.6 | 2.6 | 10.8 | 86.1 | 92 | 44 | 43 | 9 | 25 | 103 | 0 | 4 | 2 | 0 | 0 | 4 | 1 | 2.98 |
| RP | Harris, W.Harris, Will >> | 31 | 2016 | R | 67 | 53 | 0 | 4 | 2 | 2.48 | .302 | 1.28 | 9.6 | 2.1 | 11.1 | 61.2 | 65 | 20 | 17 | 3 | 14 | 75 | 0 | 3 | 1 | 0 | 0 | 1 | 5 | 1.92 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 34 | 2016 | R | 60 | 45 | 0 | 5 | 2 | 4.25 | .313 | 1.27 | 7.2 | 4.3 | 8.8 | 55.0 | 44 | 29 | 26 | 7 | 26 | 54 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 4.38 |