| SP | Lackey, J.Lackey, John # >> | 38 | 2016 | R | 94 | 16 | 16 | 3 | 7 | 4.12 | .314 | 1.36 | 9.2 | 3.2 | 7.9 | 102.2 | 104 | 51 | 47 | 12 | 36 | 89 | 0 | 0 | 0 | 0 | 9 | 1 | 2 | 3.87 |
| SP | deGrom, J.deGrom, Jacob >> | 28 | 2016 | R | 70 | 16 | 16 | 3 | 8 | 5.77 | .351 | 1.60 | 11.1 | 3.3 | 8.0 | 92.0 | 113 | 60 | 59 | 15 | 34 | 82 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 4.51 |
| SP | Richards, G.Richards, Garrett >> | 28 | 2016 | R | 56 | 15 | 15 | 5 | 4 | 5.15 | .361 | 1.66 | 10.0 | 5.0 | 9.9 | 80.1 | 89 | 46 | 46 | 13 | 44 | 88 | 0 | 0 | 0 | 0 | 6 | 3 | 8 | 4.68 |
| SP | Hernandez, F.Hernandez, Felix >> | 30 | 2016 | R | 55 | 15 | 15 | 2 | 10 | 4.84 | .372 | 1.76 | 9.6 | 6.3 | 7.3 | 80.0 | 85 | 48 | 43 | 12 | 56 | 65 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 5.46 |
| RP | Watson, T.Watson, Tony >> | 31 | 2016 | L | 66 | 42 | 0 | 3 | 2 | 3.66 | .286 | 1.20 | 7.5 | 3.4 | 7.9 | 59.0 | 49 | 25 | 24 | 9 | 22 | 52 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 4.34 |
| RP | Casilla, S.Casilla, Santiago >> | 36 | 2016 | R | 50 | 37 | 0 | 2 | 3 | 3.75 | .311 | 1.31 | 7.5 | 4.3 | 10.3 | 48.0 | 40 | 21 | 20 | 4 | 23 | 55 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 3.35 |
| RP | Robertson, D.Robertson, David >> | 31 | 2016 | R | 37 | 35 | 0 | 1 | 2 | 2.97 | .327 | 1.46 | 8.5 | 4.8 | 9.5 | 36.1 | 34 | 12 | 12 | 1 | 19 | 38 | 0 | 5 | 0 | 0 | 0 | 0 | 2 | 2.83 |
| SP | Gonzalez, G.Gonzalez, Gio >> | 31 | 2016 | L | 45 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Eovaldi, N.Eovaldi, Nathan >> | 26 | 2016 | R | 44 | 3 | 0 | 0 | 0 | 9.00 | .400 | 2.00 | 13.5 | 4.5 | 4.5 | 4.0 | 6 | 4 | 4 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| SP | Anderson, C.Anderson, Chase >> | 28 | 2016 | R | 35 | 24 | 0 | 4 | 3 | 4.81 | .322 | 1.42 | 8.3 | 4.6 | 8.8 | 39.1 | 36 | 22 | 21 | 5 | 20 | 38 | 0 | 3 | 1 | 0 | 0 | 0 | 5 | 4.26 |