| SP | Scherzer, M.Scherzer, Max >> | 32 | 2016 | R | 100 | 30 | 30 | 7 | 10 | 2.71 | .271 | 1.08 | 7.1 | 2.6 | 10.2 | 215.2 | 170 | 68 | 65 | 18 | 62 | 244 | 2 | 0 | 0 | 0 | 24 | 9 | 6 | 2.81 |
| SP | Hellickson, J.Hellickson, Jeremy # >> | 29 | 2016 | R | 76 | 29 | 29 | 11 | 10 | 4.41 | .309 | 1.30 | 9.6 | 2.1 | 6.9 | 179.2 | 191 | 90 | 88 | 27 | 42 | 137 | 0 | 0 | 0 | 0 | 15 | 8 | 5 | 4.27 |
| SP | Odorizzi, J.Odorizzi, Jake >> | 26 | 2016 | R | 76 | 29 | 29 | 5 | 15 | 5.92 | .337 | 1.48 | 10.4 | 3.0 | 7.6 | 159.2 | 184 | 106 | 105 | 21 | 53 | 134 | 1 | 0 | 0 | 1 | 9 | 7 | 0 | 4.16 |
| SP | Samardzija, J.Samardzija, Jeff # >> | 31 | 2016 | R | 68 | 29 | 29 | 6 | 9 | 5.35 | .327 | 1.43 | 10.2 | 2.6 | 7.7 | 185.0 | 210 | 113 | 110 | 26 | 54 | 159 | 2 | 0 | 0 | 0 | 11 | 6 | 4 | 4.08 |
| SU | Melancon, M.Melancon, Mark >> | 31 | 2016 | R | 87 | 76 | 0 | 5 | 2 | 3.67 | .303 | 1.26 | 9.5 | 2.0 | 7.3 | 73.2 | 77 | 36 | 30 | 9 | 16 | 59 | 0 | 6 | 6 | 0 | 0 | 3 | 4 | 3.77 |
| RP | Siegrist, K.Siegrist, Kevin >> | 26 | 2016 | L | 73 | 96 | 0 | 3 | 2 | 4.25 | .314 | 1.35 | 9.0 | 3.1 | 10.6 | 72.0 | 72 | 34 | 34 | 7 | 25 | 85 | 0 | 0 | 4 | 0 | 0 | 2 | 8 | 3.03 |
| RP | Watson, T.Watson, Tony >> | 31 | 2016 | L | 66 | 70 | 0 | 4 | 5 | 4.23 | .351 | 1.59 | 11.1 | 3.4 | 9.3 | 61.2 | 75 | 29 | 29 | 8 | 23 | 63 | 0 | 2 | 4 | 0 | 0 | 2 | 0 | 3.87 |
| RP | O'Day, D.O'Day, Darren >> | 34 | 2016 | R | 57 | 90 | 0 | 2 | 9 | 5.02 | .314 | 1.34 | 9.1 | 3.0 | 10.9 | 66.1 | 67 | 39 | 37 | 10 | 22 | 80 | 0 | 0 | 4 | 0 | 0 | 2 | 0 | 3.64 |
| SP | Davies, Z.Davies, Zach >> | 23 | 2016 | R | 54 | 28 | 0 | 2 | 9 | 3.41 | .320 | 1.37 | 8.7 | 3.7 | 7.3 | 68.2 | 66 | 26 | 26 | 8 | 28 | 55 | 0 | 1 | 0 | 0 | 0 | 3 | 3 | 4.28 |