| SP | Kluber, C.Kluber, Corey >> | 30 | 2016 | R | 95 | 34 | 34 | 15 | 12 | 2.73 | .279 | 1.12 | 7.4 | 2.8 | 9.3 | 237.2 | 194 | 74 | 72 | 21 | 73 | 244 | 3 | 0 | 0 | 3 | 25 | 9 | 2 | 3.13 |
| SP | Odorizzi, J.Odorizzi, Jake # >> | 26 | 2016 | R | 76 | 33 | 33 | 9 | 15 | 4.31 | .311 | 1.31 | 9.1 | 2.8 | 7.5 | 196.1 | 198 | 101 | 94 | 26 | 60 | 164 | 0 | 0 | 0 | 0 | 18 | 8 | 1 | 4.09 |
| SP | Hellickson, J.Hellickson, Jeremy # >> | 29 | 2016 | R | 76 | 33 | 33 | 9 | 11 | 4.62 | .307 | 1.30 | 9.3 | 2.4 | 7.3 | 206.1 | 213 | 107 | 106 | 36 | 55 | 166 | 0 | 0 | 0 | 0 | 19 | 6 | 4 | 4.55 |
| SP | Tillman, C.Tillman, Chris >> | 28 | 2016 | R | 59 | 32 | 32 | 5 | 13 | 5.48 | .357 | 1.58 | 10.4 | 3.9 | 7.2 | 177.1 | 204 | 113 | 108 | 29 | 77 | 141 | 0 | 0 | 0 | 0 | 11 | 15 | 12 | 5.10 |
| SP | Bauer, T.Bauer, Trevor >> | 25 | 2016 | R | 56 | 30 | 30 | 5 | 14 | 5.76 | .365 | 1.65 | 10.6 | 4.3 | 7.3 | 153.0 | 180 | 100 | 98 | 30 | 73 | 124 | 0 | 0 | 0 | 0 | 6 | 11 | 4 | 5.58 |
| RP | Neris, H.Neris, Hector >> | 27 | 2016 | R | 74 | 86 | 0 | 2 | 9 | 4.38 | .298 | 1.24 | 7.5 | 3.7 | 10.2 | 117.0 | 97 | 61 | 57 | 16 | 48 | 132 | 0 | 7 | 7 | 0 | 0 | 4 | 2 | 3.85 |
| RP | Salas, F.Salas, Fernando >> | 31 | 2016 | R | 54 | 82 | 0 | 7 | 6 | 4.88 | .317 | 1.34 | 9.0 | 3.2 | 7.3 | 97.2 | 97 | 54 | 53 | 16 | 34 | 79 | 0 | 3 | 5 | 0 | 0 | 5 | 1 | 4.72 |
| SP | Dickey, R.Dickey, R.A. >> | 42 | 2016 | R | 38 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Nolasco, R.Nolasco, Ricky >> | 34 | 2016 | R | 48 | 1 | 0 | 0 | 0 | 40.50 | .750 | 9.00 | - | - | - | 0.2 | 5 | 3 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Pelfrey, M.Pelfrey, Mike >> | 32 | 2016 | R | 1 | 26 | 0 | 1 | 3 | 7.53 | .402 | 1.96 | 12.7 | 5.3 | 6.6 | 34.2 | 48 | 29 | 29 | 12 | 20 | 25 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 8.06 |