| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 94 | 16 | 16 | 10 | 5 | 2.16 | .244 | 0.93 | 5.1 | 3.3 | 7.8 | 116.2 | 66 | 31 | 28 | 9 | 42 | 100 | 1 | 0 | 0 | 1 | 14 | 5 | 2 | 3.50 |
| SP | Hellickson, J.Hellickson, Jeremy # >> | 29 | 2016 | R | 76 | 16 | 16 | 10 | 4 | 3.99 | .274 | 1.10 | 8.1 | 1.9 | 6.5 | 106.0 | 95 | 49 | 47 | 23 | 22 | 76 | 0 | 0 | 0 | 0 | 10 | 3 | 4 | 5.09 |
| SP | Velasquez, V.Velasquez, Vince >> | 24 | 2016 | R | 53 | 15 | 15 | 1 | 7 | 6.91 | .368 | 1.72 | 11.7 | 3.9 | 8.7 | 70.1 | 91 | 54 | 54 | 14 | 30 | 68 | 0 | 0 | 0 | 0 | 4 | 2 | 3 | 5.03 |
| SP | Colon, B.Colon, Bartolo >> | 43 | 2016 | R | 49 | 14 | 14 | 5 | 3 | 5.54 | .333 | 1.47 | 10.6 | 2.7 | 7.7 | 78.0 | 92 | 48 | 48 | 14 | 23 | 67 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 4.58 |
| RP | Neris, H.Neris, Hector >> | 27 | 2016 | R | 74 | 37 | 0 | 3 | 3 | 4.24 | .293 | 1.22 | 7.0 | 4.1 | 12.3 | 46.2 | 36 | 22 | 22 | 5 | 21 | 63 | 0 | 4 | 1 | 0 | 0 | 1 | 2 | 3.11 |
| RP | Familia, J.Familia, Jeurys >> | 26 | 2016 | R | 53 | 36 | 0 | 2 | 0 | 3.12 | .319 | 1.41 | 9.2 | 3.6 | 11.3 | 43.1 | 44 | 15 | 15 | 7 | 17 | 54 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 3.79 |
| SP | Rodon, C.Rodon, Carlos >> | 23 | 2016 | L | 38 | 5 | 0 | 0 | 0 | 10.38 | .458 | 2.54 | 22.5 | 2.3 | 10.1 | 8.2 | 20 | 10 | 10 | 1 | 2 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.13 |
| SP | Nolasco, R.Nolasco, Ricky >> | 34 | 2016 | R | 48 | 18 | 1 | 4 | 1 | 3.61 | .299 | 1.22 | 10.4 | 0.7 | 7.4 | 52.1 | 60 | 22 | 21 | 6 | 4 | 43 | 0 | 2 | 2 | 0 | 1 | 3 | 0 | 3.25 |