| SP | Lackey, J.Lackey, John # >> | 38 | 2016 | R | 94 | 30 | 30 | 10 | 13 | 3.49 | .294 | 1.20 | 8.0 | 2.9 | 8.6 | 198.2 | 175 | 83 | 77 | 16 | 64 | 190 | 1 | 0 | 0 | 0 | 20 | 9 | 4 | 3.24 |
| SP | McCarthy, B.McCarthy, Brandon >> | 33 | 2016 | R | 63 | 30 | 30 | 1 | 8 | 3.06 | .298 | 1.22 | 6.2 | 4.8 | 9.6 | 135.1 | 93 | 46 | 46 | 4 | 72 | 144 | 0 | 0 | 0 | 0 | 0 | 7 | 7 | 3.01 |
| SP | Velasquez, V.Velasquez, Vince # >> | 24 | 2016 | R | 53 | 29 | 29 | 4 | 18 | 5.76 | .358 | 1.63 | 10.9 | 3.8 | 8.9 | 151.2 | 183 | 101 | 97 | 29 | 64 | 149 | 0 | 0 | 0 | 0 | 7 | 7 | 5 | 4.93 |
| SP | Gausman, K.Gausman, Kevin >> | 25 | 2016 | R | 52 | 28 | 28 | 7 | 10 | 5.20 | .335 | 1.41 | 8.8 | 3.9 | 8.0 | 164.1 | 160 | 106 | 95 | 29 | 71 | 145 | 0 | 0 | 0 | 0 | 13 | 17 | 3 | 5.14 |
| RP | Buchter, R.Buchter, Ryan >> | 29 | 2016 | L | 91 | 87 | 0 | 3 | 5 | 4.62 | .352 | 1.55 | 9.2 | 4.9 | 9.3 | 87.2 | 89 | 50 | 45 | 7 | 47 | 90 | 0 | 1 | 2 | 0 | 0 | 7 | 5 | 3.84 |
| RP | Belisle, M.Belisle, Matt >> | 36 | 2016 | R | 47 | 88 | 0 | 4 | 5 | 4.86 | .341 | 1.48 | 10.5 | 2.8 | 7.3 | 111.0 | 129 | 62 | 60 | 14 | 35 | 90 | 0 | 6 | 7 | 0 | 0 | 8 | 9 | 4.18 |
| RP | Robertson, D.Robertson, David >> | 31 | 2016 | R | 37 | 81 | 0 | 4 | 6 | 4.42 | .331 | 1.45 | 7.9 | 5.2 | 11.3 | 91.2 | 80 | 46 | 45 | 8 | 53 | 114 | 0 | 5 | 4 | 0 | 0 | 3 | 1 | 3.48 |
| SP | Wainwright, A.Wainwright, Adam >> | 35 | 2016 | R | 27 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Keuchel, D.Keuchel, Dallas >> | 28 | 2016 | L | 50 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Nolasco, R.Nolasco, Ricky >> | 34 | 2016 | R | 48 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Eovaldi, N.Eovaldi, Nathan >> | 26 | 2016 | R | 44 | 22 | 0 | 2 | 3 | 2.73 | .336 | 1.48 | 9.9 | 3.7 | 7.8 | 29.2 | 32 | 13 | 9 | 3 | 12 | 25 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.97 |