| SP | Scherzer, M.Scherzer, Max >> | 32 | 2016 | R | 100 | 2 | 2 | 2 | 0 | 3.14 | .246 | 0.84 | 5.8 | 1.9 | 15.4 | 14.1 | 9 | 5 | 5 | 2 | 3 | 24 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 2.50 |
| SP | Fernandez, J.Fernandez, Jose >> | 24 | 2016 | R | 90 | 2 | 2 | 1 | 1 | 4.38 | .327 | 1.46 | 9.0 | 4.5 | 11.3 | 12.1 | 12 | 6 | 6 | 2 | 6 | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.17 |
| SP | Roark, T.Roark, Tanner >> | 29 | 2016 | R | 80 | 2 | 2 | 1 | 1 | 6.23 | .361 | 1.69 | 11.8 | 3.5 | 6.2 | 13.0 | 17 | 11 | 9 | 0 | 5 | 9 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2.77 |
| SP | Martinez, C.Martinez, Carlos >> | 25 | 2016 | R | 74 | 1 | 1 | 1 | 0 | 0.00 | .250 | 0.88 | 5.6 | 2.3 | 10.1 | 8.0 | 5 | 0 | 0 | 0 | 2 | 9 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1.88 |
| SP | Santana, E.Santana, Ervin >> | 33 | 2016 | R | 65 | 1 | 1 | 0 | 1 | 4.26 | .269 | 0.95 | 9.0 | 0.0 | 7.5 | 6.1 | 6 | 3 | 3 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1.83 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 100 | 6 | 0 | 0 | 0 | 0.00 | .100 | 0.33 | 3.0 | 0.0 | 9.0 | 3.0 | 1 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 |
| RP | Osuna, R.Osuna, Roberto >> | 21 | 2016 | R | 86 | 6 | 0 | 0 | 0 | 12.00 | .500 | 2.67 | 21.0 | 3.0 | 12.0 | 3.0 | 7 | 4 | 4 | 2 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 11.00 |
| RP | Torres, C.Torres, Carlos >> | 33 | 2016 | R | 59 | 3 | 0 | 0 | 0 | 0.00 | .357 | 1.33 | 3.0 | 9.0 | 9.0 | 3.0 | 1 | 0 | 0 | 0 | 3 | 3 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.00 |
| SP | Buchholz, C.Buchholz, Clay >> | 32 | 2016 | R | 45 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |