| SP | Kluber, C.Kluber, Corey >> | 30 | 2016 | R | 95 | 31 | 31 | 11 | 12 | 3.50 | .266 | 1.06 | 6.6 | 3.0 | 10.0 | 206.0 | 150 | 80 | 80 | 17 | 68 | 228 | 3 | 0 | 0 | 1 | 18 | 6 | 6 | 2.94 |
| SP | Fernandez, J.Fernandez, Jose # >> | 24 | 2016 | R | 90 | 29 | 29 | 13 | 8 | 3.62 | .285 | 1.15 | 7.4 | 3.0 | 10.4 | 176.1 | 144 | 72 | 71 | 19 | 59 | 203 | 0 | 0 | 0 | 0 | 19 | 8 | 4 | 3.24 |
| SP | Porcello, R.Porcello, Rick >> | 27 | 2016 | R | 88 | 29 | 29 | 9 | 13 | 4.23 | .285 | 1.13 | 8.4 | 1.8 | 7.8 | 189.1 | 177 | 91 | 89 | 22 | 37 | 164 | 2 | 0 | 0 | 0 | 16 | 12 | 6 | 3.56 |
| SP | Sanchez, A.Sanchez, Aaron † >> | 23 | 2016 | R | 80 | 29 | 29 | 19 | 7 | 3.93 | .301 | 1.23 | 7.3 | 3.8 | 7.4 | 176.1 | 143 | 77 | 77 | 14 | 74 | 145 | 1 | 0 | 0 | 0 | 18 | 11 | 1 | 3.84 |
| SP | Martinez, C.Martinez, Carlos >> | 25 | 2016 | R | 74 | 27 | 27 | 9 | 8 | 5.69 | .352 | 1.60 | 10.4 | 4.1 | 7.3 | 140.2 | 161 | 91 | 89 | 14 | 64 | 113 | 0 | 0 | 0 | 0 | 12 | 4 | 4 | 4.14 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 100 | 62 | 0 | 4 | 4 | 2.34 | .255 | 0.99 | 6.6 | 2.4 | 8.9 | 65.1 | 48 | 19 | 17 | 6 | 17 | 64 | 0 | 38 | 7 | 0 | 0 | 2 | 1 | 3.11 |
| RP | Salas, F.Salas, Fernando >> | 31 | 2016 | R | 54 | 33 | 0 | 2 | 2 | 3.44 | .252 | 0.95 | 6.3 | 2.5 | 6.5 | 36.2 | 25 | 16 | 14 | 3 | 10 | 26 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.64 |
| SP | Wright, S.Wright, Steven >> | 31 | 2016 | R | 66 | 9 | 1 | 2 | 1 | 1.89 | .288 | 1.16 | 7.1 | 3.3 | 6.6 | 19.0 | 15 | 4 | 4 | 2 | 7 | 14 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 4.16 |