| SP | Scherzer, M.Scherzer, Max >> | 32 | 2016 | R | 100 | 16 | 16 | 5 | 5 | 2.55 | .243 | 0.94 | 6.6 | 1.9 | 8.8 | 116.1 | 85 | 33 | 33 | 8 | 24 | 114 | 1 | 0 | 0 | 0 | 13 | 3 | 1 | 2.63 |
| SP | Fulmer, M.Fulmer, Michael >> | 23 | 2016 | R | 85 | 16 | 16 | 8 | 3 | 3.78 | .286 | 1.15 | 7.9 | 2.4 | 7.2 | 100.0 | 88 | 43 | 42 | 10 | 27 | 80 | 0 | 0 | 0 | 0 | 10 | 5 | 1 | 3.66 |
| SP | Roark, T.Roark, Tanner >> | 29 | 2016 | R | 80 | 15 | 15 | 5 | 6 | 4.41 | .354 | 1.59 | 9.7 | 4.8 | 7.4 | 81.2 | 87 | 45 | 40 | 5 | 43 | 67 | 0 | 0 | 0 | 0 | 9 | 4 | 2 | 3.89 |
| SP | Martinez, C.Martinez, Carlos >> | 25 | 2016 | R | 74 | 15 | 15 | 5 | 5 | 4.67 | .297 | 1.25 | 8.5 | 2.8 | 7.2 | 86.2 | 81 | 45 | 45 | 15 | 27 | 69 | 0 | 0 | 0 | 0 | 8 | 2 | 3 | 4.67 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 100 | 31 | 0 | 4 | 4 | 2.17 | .211 | 0.78 | 4.1 | 2.9 | 9.2 | 37.1 | 17 | 9 | 9 | 6 | 12 | 38 | 0 | 13 | 0 | 0 | 0 | 1 | 0 | 4.11 |
| RP | Gregerson, L.Gregerson, Luke >> | 32 | 2016 | R | 90 | 52 | 0 | 1 | 0 | 4.40 | .299 | 1.28 | 7.1 | 4.4 | 10.9 | 47.0 | 37 | 23 | 23 | 3 | 23 | 57 | 0 | 3 | 2 | 0 | 0 | 0 | 6 | 2.87 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 72 | 35 | 0 | 6 | 1 | 0.96 | .194 | 0.72 | 5.1 | 1.5 | 10.9 | 37.1 | 21 | 4 | 4 | 1 | 6 | 45 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.41 |
| RP | Barraclough, K.Barraclough, Kyle >> | 26 | 2016 | R | 70 | 19 | 0 | 0 | 1 | 2.41 | .282 | 1.18 | 5.5 | 5.5 | 12.5 | 18.2 | 11 | 5 | 5 | 0 | 11 | 25 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.06 |