| SP | Strasburg, S.Strasburg, Stephen >> | 27 | 2016 | R | 93 | 30 | 30 | 9 | 16 | 4.05 | .323 | 1.41 | 8.4 | 4.3 | 10.2 | 180.0 | 167 | 84 | 81 | 17 | 86 | 203 | 0 | 0 | 0 | 0 | 13 | 5 | 5 | 3.49 |
| SP | Teheran, J.Teheran, Julio >> | 25 | 2016 | R | 89 | 30 | 30 | 12 | 7 | 2.81 | .266 | 1.06 | 7.1 | 2.5 | 7.8 | 208.1 | 164 | 69 | 65 | 21 | 57 | 180 | 0 | 0 | 0 | 0 | 22 | 6 | 2 | 3.49 |
| SP | Syndergaard, N.Syndergaard, Noah >> | 23 | 2016 | R | 83 | 30 | 29 | 8 | 6 | 4.64 | .324 | 1.41 | 9.9 | 2.8 | 10.0 | 168.2 | 185 | 91 | 87 | 17 | 53 | 187 | 0 | 0 | 0 | 0 | 13 | 5 | 6 | 3.13 |
| SP | deGrom, J.deGrom, Jacob >> | 28 | 2016 | R | 70 | 31 | 29 | 7 | 11 | 4.22 | .308 | 1.27 | 9.0 | 2.5 | 7.7 | 185.1 | 184 | 88 | 87 | 23 | 52 | 158 | 0 | 0 | 0 | 0 | 19 | 12 | 5 | 3.95 |
| SP | Gonzalez, G.Gonzalez, Gio >> | 31 | 2016 | L | 45 | 31 | 28 | 5 | 9 | 5.19 | .343 | 1.49 | 10.2 | 3.3 | 7.9 | 126.2 | 143 | 75 | 73 | 23 | 46 | 110 | 0 | 0 | 0 | 0 | 0 | 9 | 2 | 4.94 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 97 | 90 | 0 | 10 | 2 | 2.18 | .295 | 1.23 | 7.8 | 3.3 | 8.6 | 124.0 | 107 | 30 | 30 | 4 | 46 | 118 | 0 | 4 | 4 | 0 | 0 | 3 | 13 | 2.70 |
| RP | Uehara, K.Uehara, Koji >> | 41 | 2016 | R | 89 | 87 | 0 | 7 | 5 | 3.48 | .259 | 1.03 | 7.0 | 2.3 | 10.8 | 113.2 | 88 | 45 | 44 | 14 | 29 | 136 | 0 | 8 | 2 | 0 | 0 | 2 | 2 | 3.03 |
| RP | Neris, H.Neris, Hector >> | 27 | 2016 | R | 74 | 79 | 0 | 7 | 8 | 3.67 | .297 | 1.22 | 7.1 | 4.0 | 9.3 | 90.2 | 71 | 39 | 37 | 8 | 40 | 93 | 0 | 7 | 4 | 0 | 0 | 4 | 4 | 3.56 |
| RP | Diekman, J.Diekman, Jake >> | 29 | 2016 | L | 69 | 68 | 0 | 7 | 6 | 3.30 | .314 | 1.32 | 8.1 | 3.8 | 8.6 | 73.2 | 66 | 28 | 27 | 5 | 31 | 70 | 0 | 11 | 1 | 0 | 0 | 4 | 1 | 3.41 |