| SP | Strasburg, S.Strasburg, Stephen † >> | 27 | 2016 | R | 93 | 34 | 34 | 15 | 12 | 3.79 | .301 | 1.25 | 8.8 | 2.5 | 10.0 | 216.1 | 210 | 101 | 91 | 32 | 60 | 241 | 0 | 0 | 0 | 0 | 22 | 10 | 5 | 3.67 |
| SP | Estrada, M.Estrada, Marco # >> | 33 | 2016 | R | 90 | 33 | 33 | 13 | 7 | 3.39 | .276 | 1.11 | 7.3 | 2.7 | 9.0 | 210.0 | 170 | 83 | 79 | 25 | 64 | 211 | 1 | 0 | 0 | 0 | 22 | 6 | 4 | 3.54 |
| SP | Teheran, J.Teheran, Julio >> | 25 | 2016 | R | 89 | 32 | 32 | 12 | 11 | 4.17 | .304 | 1.22 | 8.7 | 2.3 | 8.4 | 207.0 | 201 | 99 | 96 | 29 | 52 | 193 | 1 | 0 | 0 | 0 | 16 | 18 | 3 | 3.97 |
| SP | De La Rosa, R.De La Rosa, Rubby >> | 27 | 2016 | R | 73 | 31 | 31 | 2 | 6 | 3.99 | .301 | 1.23 | 8.2 | 3.0 | 9.8 | 128.2 | 116 | 59 | 57 | 18 | 42 | 140 | 0 | 0 | 0 | 0 | 0 | 8 | 3 | 3.81 |
| RP | Britton, Z.Britton, Zach † >> | 28 | 2016 | L | 97 | 92 | 0 | 11 | 3 | 3.53 | .302 | 1.24 | 6.8 | 4.3 | 9.4 | 125.0 | 95 | 50 | 49 | 11 | 60 | 130 | 0 | 12 | 4 | 0 | 0 | 7 | 13 | 3.67 |
| RP | Osuna, R.Osuna, Roberto >> | 21 | 2016 | R | 86 | 84 | 0 | 8 | 6 | 3.35 | .255 | 0.94 | 7.0 | 1.4 | 8.3 | 110.0 | 86 | 43 | 41 | 8 | 17 | 102 | 0 | 6 | 3 | 0 | 0 | 10 | 6 | 2.83 |
| RP | Doolittle, S.Doolittle, Sean >> | 29 | 2016 | L | 68 | 58 | 0 | 5 | 1 | 2.29 | .269 | 1.08 | 7.5 | 2.3 | 9.0 | 70.2 | 58 | 18 | 18 | 6 | 18 | 70 | 0 | 10 | 0 | 0 | 0 | 2 | 1 | 2.97 |
| RP | Hochevar, L.Hochevar, Luke >> | 33 | 2016 | R | 65 | 44 | 0 | 5 | 1 | 3.59 | .267 | 1.07 | 6.9 | 2.9 | 12.3 | 47.2 | 36 | 19 | 19 | 7 | 15 | 64 | 0 | 6 | 2 | 0 | 0 | 1 | 3 | 3.23 |